Clinically Evident, Non-terminal Infections with Herpesviruses and the Wart Virus in Immunosuppressed Renal Allograft Recipients
TL;DR: The clinical incidence of herpes simplex lesions, herpes zoster, cytomegalovirus infection, and warts has been determined in a group of renal allograft recipients and no factors other than immunosuppression and steroid therapy could be identified with certainty as predisposing to these infections.
Abstract: The clinical incidence of herpes simplex lesions, herpes zoster, cytomegalovirus infection, and warts has been determined in a group of renal allograft recipients. Herpes simplex lesions appeared to be no more common after transplantation than before in those patients subject to recurrent attacks. Among 74 patients there were seven cases of herpes zoster and seven serologically proved cases of cytomegalovirus infection with clinical manifestations. The incidence of warts increased with length of time after transplantation, 42% of patients being affected more than one year after transplantation. All of the viral infections studied behaved as in healthy adults, and serious illness, dissemination, wide-spread lesions, and complications were not seen. No factors other than immunosuppression and steroid therapy could be identified with certainty as predisposing to these infections.
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TL;DR: The isolation of a new papovavirus from the urine of a renal allograft recipient with ureteric obstruction is described and this virus is not identical with any of the previously described members of the polyoma subgroup.
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TL;DR: The view that common warts (verrucae vulgares, juvenile warts, and genital warts are caused by the same virus and that differences in appearance are the result of variations in location and host reactivity has been shared by dermatologists for several decades.
Abstract: The view that common warts (verrucae vulgares), juvenile warts (verrucae planae), and genital warts (condylomata acuminata) are caused by the same virus and that differences in appearance are the result of variations in location and host reactivity has been shared by dermatologists for several decades (Frey, 1924; Waelsch and Habermann, 1924; Young, 1964; Rowson and Mahy, 1967; Nasemann, 1974; Lever and Schaumburg-Lever, 1975). This has probably reduced the interest in specific types of human papillomas.
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TL;DR: Organ transplantation has evolved into the best opportunity for rehabilitation for patients with end-stage disease of an increasing number of organs: today, the kidney, heart, liver, and lungs; tomorrow, the pancreas or pancreatic islets and small bowel.
269 citations
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TL;DR: There was no evidence of any beneficial effect of a rise in haemoglobin level on psychomotor function or on symptoms of anaemia, and anaemia is probably a rare cause of symptoms or impairment in psychom motor function in the community.
Abstract: A variety of aspects of psychomotor function were assessed in 47 women before and after iron therapy. These women, all of whom had initial haemoglobin levels below 10·5 g./100 ml., had been drawn from a population sample of 2,283 women seen at a haematological screening survey. There was no evidence of any beneficial effect of a rise in haemoglobin level on psychomotor function or on symptoms. Possibly this is because if an effect does occur it is unlikely to be apparent unless the haemoglobin level is very low. If this is true then anaemia is probably a rare cause of symptoms or impairment in psychomotor function in the community.
42 citations