CNS synaptogenesis promoted by glia-derived cholesterol
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...The importance of astrocytic ApoE is also emphasized by its role in the genesis and functionality of synapse...
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..., 2004), as well as with soluble astrocyte-derived signals such as cholesterol (Mauch et al., 2001) and an as yet unidentified signal reported here, that further help to promote preand postsynaptic function....
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...In previous studies, we found that, when purified rat retinal ganglion cells (RGCs) are cultured in defined serum-free conditions that fully support their survival and growth, they form few synapses unless cultured with astrocytes, as measured by electrophysiology, FM1-43 imaging, immunostaining, and electron microscopy (Mauch et al., 2001; Nagler et al., 2001; Pfrieger and Barres, 1997; Ullian et al., 2004a)....
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...To test whether ApoE-containing particles could be responsible for the activity as previously reported (Mauch et al., 2001), we immunodepleted ApoE-containing complexes from ACM....
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...…conditions that fully support their survival and growth, they form few synapses unless cultured with astrocytes, as measured by electrophysiology, FM1-43 imaging, immunostaining, and electron microscopy (Mauch et al., 2001; Nagler et al., 2001; Pfrieger and Barres, 1997; Ullian et al., 2004a)....
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...However, cholesterol does strongly enhance synaptic efficacy, as previously reported (Mauch et al., 2001; Supplemental Figure S1)....
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