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Proceedings ArticleDOI

Co-existence of two lamellar phases in phospholipid multilayers induced by an ionic liquid

05 Nov 2020-Vol. 2265, Iss: 1, pp 030032
TL;DR: In this paper, the effect of ionic liquid tetrabutylammonium methanesulfonate (TAM) on a model cellular membrane composed of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) lipids was studied.
Abstract: Ionic liquids (ILs) have recently become very popular molecules because of their fascinating properties, which can be exploited in industrial and biomedical applications. There are several recent reports which suggest strong interaction of these molecules with bio-membrane. This interaction, which leads to complete disruption of the cell membrane leading to cell death, can be very useful in designing anti-microbial agents. Here, we have studied the effect of an ionic liquid tetrabutylammonium methanesulfonate (TAM) on a model cellular membrane composed of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) lipids. While differential scanning calorimetry study indicates a fluidity effect, the x-ray reflectivity measurements exhibit the formation of a new phase in the membrane.
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Journal ArticleDOI
TL;DR: The accumulated data on the biological activity of ionic liquids, including their antimicrobial and cytotoxic properties, are discussed in view of possible applications in drug synthesis and drug delivery systems.
Abstract: Ionic liquids are remarkable chemical compounds, which find applications in many areas of modern science. Because of their highly tunable nature and exceptional properties, ionic liquids have become essential players in the fields of synthesis and catalysis, extraction, electrochemistry, analytics, biotechnology, etc. Apart from physical and chemical features of ionic liquids, their high biological activity has been attracting significant attention from biochemists, ecologists, and medical scientists. This Review is dedicated to biological activities of ionic liquids, with a special emphasis on their potential employment in pharmaceutics and medicine. The accumulated data on the biological activity of ionic liquids, including their antimicrobial and cytotoxic properties, are discussed in view of possible applications in drug synthesis and drug delivery systems. Dedicated attention is given to a novel active pharmaceutical ingredient-ionic liquid (API-IL) concept, which suggests using traditional drugs in ...

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