Coagulation and metastasis: what does the experimental literature tell us?
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TLDR
This work revisits the literature on coagulation in the light of recent studies in which treatment of clinical cohorts with anticoagulant drugs led to diminished metastasis.Abstract:
Inhibition of coagulation greatly limits cancer metastasis in many experimental models. Cancer cells trigger coagulation, through expression of tissue factor or P-selectin ligands that have correlated with worse prognosis in human clinical studies. Cancer cells also affect coagulation through expression of thrombin and release of microparticles that augment coagulation. In the cancer-bearing host, coagulation facilitates tumour progression through release of platelet granule contents, inhibition of Natural Killer cells and recruitment of macrophages. We are revisiting this literature in the light of recent studies in which treatment of clinical cohorts with anticoagulant drugs led to diminished metastasis.read more
Citations
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Crossing the endothelial barrier during metastasis
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Exosome-Mediated Metastasis: Communication from a Distance.
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Intravascular Survival and Extravasation of Tumor Cells.
TL;DR: The current understanding of the cellular and molecular mechanisms that allow tumor cells to survive in the intravascular environment and that mediate and promote tumor cell extravasation are reviewed.
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Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis
Silvia Guglietta,Andrea Chiavelli,Elena Zagato,Carsten Krieg,Sara Gandini,Paola Simona Ravenda,Barbara Bazolli,Bao Lu,Giuseppe Penna,Maria Rescigno,Maria Rescigno +10 more
TL;DR: This study provides a mechanistic explanation for the tumour-promoting effects of hypercoagulation, which could be used as a new biomarker or as a therapeutic target.
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The immune system in cancer metastasis: friend or foe?
TL;DR: Classic and new observations are reviewed, describing the links between the immune system and metastasis that inform the development of cancer therapies.
References
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