Journal ArticleDOI
Cobalt-catalyzed tandem radical cyclization and cross-coupling reaction: Its application to benzyl-substituted heterocycles
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This article is published in Journal of the American Chemical Society.The article was published on 2001-05-10. It has received 167 citations till now. The article focuses on the topics: Radical cyclization & Coupling reaction.read more
Citations
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Catalysis of Radical Reactions: A Radical Chemistry Perspective.
Armido Studer,Dennis P. Curran +1 more
TL;DR: This work critically address both catalyst-free and catalytic radical reactions through the lens of radical chemistry, using basic principles of kinetics and thermodynamics to address problems of initiation, propagation, and inhibition of radical chains.
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Low-valent cobalt catalysis: new opportunities for C-H functionalization.
Ke Gao,Naohiko Yoshikai +1 more
TL;DR: This Account summarizes the research on the development of three different types of C-H functionalization reactions using low-valent cobalt catalysts, and highlights a distinct regioselectivity of the cobalt catalyst compared with typical rhodium and ruthenium catalysts.
Journal ArticleDOI
Secondary alkyl halides in transition-metal-catalyzed cross-coupling reactions.
Alena Rudolph,Mark Lautens +1 more
TL;DR: This Minireview summarizes selected examples of the use of secondary alkyl halides as electrophiles in cross-coupling reactions, with emphasis on the transition metals employed, the mechanistic pathways involved, and implications in terms of the stereochemical outcome of reactions.
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Cobalt-Catalyzed Cross-Coupling Reactions
Gerard Cahiez,Alban Moyeux +1 more
TL;DR: Alkenylation of Acetylenic Grignard Reagents 1447 6.1.3.
Journal ArticleDOI
The Persistent Radical Effect in Organic Synthesis
TL;DR: Although great progress has been achieved over the years in enantioselective radical chemistry, the radical-metal crossover approach offers advantages, in particular considering the non-existing background coupling leading to racemic compounds.
References
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Nonstabilized Alkyl Complexes and Alkyl‐Cyano‐Ate Complexes of Iron(II) and Cobalt(II) as New Reagents in Organic Synthesis
TL;DR: Alkyl transition metal reagents are being increasingly used for alkylations in organic synthesis as discussed by the authors, and they have various advantages over alkyllithium and alkyl-magnesium reagents including higher selectivity, lower basicity, and their willingness to undergo oxidative addition with electrophiles.
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Cobalt-catalyzed alkenylation of zinc organometallics
TL;DR: In this article, the cross-coupling reactions with either E- or Z-alkenyl iodides in the presence of catalytic amounts of Co(acacac)2 or Co(ACac)3 in THF:NMP at 55 °C leading to polyfunctional alkenes with retention of the stereochemistry of the double bond.
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Trialkylmanganate-Induced Cyclization of Allyl 2-Iodophenyl Ether, N,N-Diallyl-2-iodoaniline, and alpha-Iodo Acetal.
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Formation of organomagnesium compounds via EtMgBr-mediated radical cyclization of allyl beta-iodoacetals
TL;DR: Treatment of allyl beta-iodoacetals with ethylmagnesium bromide in THF and the reaction in DME provided tetrahydrofuranylmethylmagnesium compounds in good yields.