Journal ArticleDOI
Cobalt(III)-Catalyzed C-6 Alkenylation of 2-Pyridones by Using Terminal Alkyne with High Regioselectivity.
Smruti Ranjan Mohanty,Namrata Prusty,Lokesh Gupta,Pragati Biswal,Ponneri Chandrababu Ravikumar +4 more
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TLDR
In this paper, a Co(III)-catalyzed alkenylation of 2-pyridones by using terminal alkyne as a reaction partner with high regioselectivity was demonstrated for the first time.Abstract:
Co(III)-catalyzed alkenylation of 2-pyridones by using terminal alkyne as a reaction partner with high regioselectivity has been demonstrated for the first time. The reaction conditions are mild and compatible with a wide range of substrate combinations. It also shows good functional group tolerance. It proceeds through cyclometalation followed by alkyne insertion and protodemetalation steps. The formation of five- and seven-membered cobaltacycle intermediates was also detected through high-resolution mass spectrometry.read more
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Diverse reactivity of alkynes in C-H activation reactions.
Shyam Kumar Banjare,Pranav Shridhar Mahulkar,Tanmayee Nanda,Bedadyuti Vedvyas Pati,Lamphiza O Najiar,Ponneri Chandrababu Ravikumar +5 more
TL;DR: Alkynes have a prominent role as a coupling partner in the transition metal-catalysed directed C-H activation reactions as discussed by the authors , which makes them one of the most successful coupling partners in terms of the number of useful transformations.
Journal ArticleDOI
Mechanochemical Ruthenium-Catalyzed Ortho-Alkenylation of N-Heteroaryl Arenes with Alkynes under Ball-Milling Conditions.
TL;DR: The mechanochemical, solvent-free Ru(II)-catalyzed alkenylation of N-heteroaryl arenes with alkynes has been successfully described and exhibited excellent functional group compatibility, broad substrate scope, shorter reaction times, and no external heating.
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Ru-Catalyzed C-H alkenylation on the arene ring of pirfenidone using pyridone as a directing group.
Raziullah,Rohit Kumar,Ashfaq Ahmad,Himangsu Sekhar Dutta,Anushka Rastogi,Manoj Kumar Gangwar,Dipankar Koley +6 more
TL;DR: In this paper , the N-aryl ring of pirfenidone with internal alkynes using ruthenium catalyst was used to functionalize the arene ring of the drug.
Journal ArticleDOI
Switching the Reactivity of the Nickel-Catalyzed Reaction of 2-Pyridones with Alkynes: Easy Access to Polyaryl/Polyalkyl Quinolinones.
Namrata Prusty,Smruti Ranjan Mohanty,Shyam Kumar Banjare,Tanmayee Nanda,Ponneri Chandrababu Ravikumar +4 more
TL;DR: In this article , a Ni-catalyzed C6 followed by C5 cascade C-H activation/[2 + 2 + 2] annulation of 2-pyridone with alkynes has been achieved.
Journal ArticleDOI
Co(III)-catalysed regioselective linear C(8)-H olefination of isoquinolone with terminal aromatic and aliphatic alkynes.
Devesh Chandra,Devesh Chandra,Nikunj Kumar,Sumit,Sumit,Diksha Parmar,Diksha Parmar,Puneet Gupta,Upendra Sharma,Upendra Sharma +9 more
TL;DR: In this paper, a regioselective C8 linear olefination of isoquinoline-1H-2-one with terminal (aromatic and aliphatic) alkynes is reported under Co(III) catalysis.
References
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NMR Chemical Shifts of Common Laboratory Solvents as Trace Impurities.
TL;DR: 1H and 13C chemical shifts of what are, in the authors' experience, the most popular “extra peaks” in a variety of commonly used NMR solvents are collected, in the hope that this will be of assistance to the practicing chemist.
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On the Interpretation of Deuterium Kinetic Isotope Effects in C ? H Bond Functionalizations by Transition-Metal Complexes
Eric M. Simmons,John F. Hartwig +1 more
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3d Transition Metals for C-H Activation.
Parthasarathy Gandeepan,Thomas Müller,Daniel Zell,Gianpiero Cera,Svenja Warratz,Lutz Ackermann +5 more
TL;DR: A comprehensive overview on first row transition metal catalysts for C-H activation until summer 2018 is provided.
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Mild metal-catalyzed C–H activation: examples and concepts
TL;DR: This review presents the current state of the art in this field and detail C-H activation transformations reported since 2011 that proceed either at or below ambient temperature, in the absence of strongly acidic or basic additives or without strong oxidants.
Journal ArticleDOI
Cobalt-Catalyzed C―H Activation
TL;DR: Recent progress in the field of organometallic cobalt-catalyzed C–H activation is reviewed until November 2015.