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Journal ArticleDOI

Coelonin, A 9,10-dihydrophenanthrene from the orchids Coelogyne ochracea and Coelogyne elata

01 Jan 1982-Phytochemistry (Pergamon)-Vol. 21, Iss: 2, pp 478-480
TL;DR: 2,7-Dihydroxy-4-methoxy-9,10-dihydrophenanthrene was isolated and identified from the whole plant of Coelogyne ochracea and C. elata.
About: This article is published in Phytochemistry.The article was published on 1982-01-01. It has received 77 citations till now.
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Journal ArticleDOI
TL;DR: The present study furnishes an overview of the hydroxy or/and methoxy-substituted 9,10-dihydro/phenanthrene, methylated, prenylated and other monomeric derivatives, dimeric and trimeric phenanthrenes and their biological activities.

282 citations

Journal ArticleDOI
TL;DR: An amorphous phenanthrene, named nudol has been isolated from Eulophia nuda, Eria carinata and E. stricta and was identified as 2,7-dihydroxy-3,4-dimethoxyphenanthrene.

74 citations

Journal ArticleDOI
TL;DR: Three new substituted bibenzyls (1,2-diarylethanes) aloifol I and aloIFol II and a new substituted 9,10-dihydrophenanthrene, 6-O-methylcoelonin in addition to batatasin III, coel onin and gigantol have been isolated and characterized.

70 citations

Journal ArticleDOI
TL;DR: In this article, a methanol extract from the whole plant of Dendrobium formosum Roxb. ex Lindl, Orchidaceae, showed inhibitory potential against α-glucosidase and pancreatic lipase enzymes.
Abstract: A methanol extract from the whole plant of Dendrobium formosum Roxb. ex Lindl., Orchidaceae, showed inhibitory potential against α-glucosidase and pancreatic lipase enzymes. Chromatographic separation of the extract resulted in the isolation of twelve phenolic compounds. The structures of these compounds were determined through analysis of NMR and HR-ESI-MS data. All of the isolates were evaluated for their α-glucosidase and pancreatic lipase inhibitory activities, as well as glucose uptake stimulatory effect. Among the isolates, 5-methoxy-7-hydroxy-9,10-dihydro-1,4-phenanthrenequinone (12) showed the highest α-glucosidase and pancreatic lipase inhibitory effects with an IC50 values of 126.88 ± 0.66 μM and 69.45 ± 10.14 μM, respectively. An enzyme kinetics study was conducted by the Lineweaver-Burk plot method. The kinetics studies revealed that compound 12 was a non-competitive inhibitor of α-glucosidase and pancreatic lipase enzymes. Moreover, lusianthridin at 1 and 10 μg/ml and moscatilin at 100 μg/ml showed glucose uptake stimulatory effect without toxicity on L6 myotubes. This study is the first report on the phytochemical constituents and anti-diabetic and anti-obesity activities of D. formosum.

68 citations


Cites result from "Coelonin, A 9,10-dihydrophenanthren..."

  • ...Its structure was identified by comparison of NMR data with published values (Majumder and Joardar, 1985)....

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