Cognitive Disorders and Dementia in CKD: The Neglected Kidney-Brain Axis
Citations
370 citations
Cites background from "Cognitive Disorders and Dementia in..."
...Other considered it a new candidate risk factor (Bugnicourt et al., 2013)....
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Cites background from "Cognitive Disorders and Dementia in..."
...Most [129-133], but not all [134] of these studies found that low kidney function was related to an increased risk of dementia, AD, or cognitive decline....
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...Mechanisms linking CKD and dementia include shared risk factors (such as hypertension, arterial stiffness, smoking, and obesity) and direct consequences of CKD (such as chronic inflammation, hemodynamic changes, anemia, and uremic toxins) [129]....
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210 citations
Cites background from "Cognitive Disorders and Dementia in..."
...Recent evidence indicates that endogenous uremic toxins (7,8), atherotoxins (9) and oncometabolites (10) arising from natural metabolism or food-gut microflora interactions appear to account for a significant portion of kidney disease, cardiovascular disease, diabetes, dementia and cancer (which are among the leading causes of death and disease in the developed world)....
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References
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