Journal ArticleDOI
Cold atmospheric plasma in cancer therapya)
Michael Keidar,Alex Shashurin,Olga Volotskova,Mary Ann Stepp,Priya Srinivasan,Anthony D. Sandler,Barry Trink +6 more
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TLDR
Study indicate that the mechanism of action of cold plasma on cancer cells is related to generation of reactive oxygen species with possible induction of the apoptosis pathway and the cancer cells are more susceptible to the effects of CAP.Abstract:
Recent progress in atmospheric plasmas has led to the creation of cold plasmas with ion temperature close to room temperature. This paper outlines recent progress in understanding of cold plasma physics as well as application of cold atmospheric plasma (CAP) in cancer therapy. Varieties of novel plasma diagnostic techniques were developed recently in a quest to understand physics of CAP. It was established that the streamer head charge is about 108 electrons, the electrical field in the head vicinity is about 107 V/m, and the electron density of the streamer column is about 1019 m−3. Both in-vitro and in-vivo studies of CAP action on cancer were performed. It was shown that the cold plasma application selectively eradicates cancer cells in-vitro without damaging normal cells and significantly reduces tumor size in-vivo. Studies indicate that the mechanism of action of cold plasma on cancer cells is related to generation of reactive oxygen species with possible induction of the apoptosis pathway. It is also shown that the cancer cells are more susceptible to the effects of CAP because a greater percentage of cells are in the S phase of the cell cycle.read more
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Reactive species in non-equilibrium atmospheric-pressure plasmas: Generation, transport, and biological effects
Xinpei Lu,Xinpei Lu,George V. Naidis,Mounir Laroussi,Stephan Reuter,David B. Graves,Ken Ostrikov +6 more
TL;DR: In this paper, the most important mechanisms of generation and transport of the key species in the plasmas of atmospheric-pressure plasma jets and other non-equilibrium atmospheric pressure plasms are introduced and examined from the viewpoint of their applications in plasma hygiene and medicine and other relevant fields.
Journal ArticleDOI
Guided ionization waves: Theory and experiments
TL;DR: In this paper, the authors discuss the fundamental physics of the guided streamer-like structures, which are produced in cold atmospheric-pressure plasma jets, and introduce the basic theories and recent advances on the experimental and computational studies of guided streamers, in particular related to the propagation dynamics of ionization waves and various parameters of relevance to plasma streamers.
Journal ArticleDOI
Plasma for cancer treatment
TL;DR: This review summarizes the state of the art of this emerging field of cold atmospheric plasma medicine in cancer, presenting various aspects of CAP application in cancer such as the role of reactive species, cell cycle modification, and computational oncology applied to CAP.
Journal ArticleDOI
The kINPen—a review on physics and chemistry of the atmospheric pressure plasma jet and its applications
Journal ArticleDOI
Clinical Plasma Medicine: State and Perspectives of in Vivo Application of Cold Atmospheric Plasma
TL;DR: There are four cold atmospheric plasma sources which were tested comprehensively in animals as well as human beings with respect both to its therapeutic potential and the safety of its application.
References
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Journal ArticleDOI
Applied Plasma Medicine
Gregory Fridman,Gary Friedman,Alexander Gutsol,Anatoly B. Shekhter,Victor N. Vasilets,Alexander Fridman +5 more
TL;DR: Non-equilibrium plasmas will be shown to be non-destructive to tissue, safe, and effective in inactivation of various parasites and foreign organisms.
Journal ArticleDOI
Plasma medicine: an introductory review
Michael G. Kong,Gmw Gerrit Kroesen,Gregor E. Morfill,Tetyana Nosenko,Tetsuji Shimizu,van J Jan Dijk,Julia L. Zimmermann +6 more
TL;DR: This introductory review on plasma health care is intended to provide the interested reader with a summary of the current status of this emerging field, its scope, and its broad interdisciplinary approach, ranging from plasma physics, chemistry and technology, to microbiology, biochemistry, biophysics, medicine and hygiene.
Journal ArticleDOI
Cold plasma selectivity and the possibility of a paradigm shift in cancer therapy
Michael Keidar,R Walk,Alexey Shashurin,Priya Srinivasan,Anthony D. Sandler,Santanu Dasgupta,Rajani Ravi,Rafael Guerrero-Preston,Barry Trink +8 more
TL;DR: The development of cold plasma tumour ablation has the potential of shifting the current paradigm of cancer treatment and enabling the transformation ofcancer treatment technologies by utilisation of another state of matter.
Journal ArticleDOI
Room-temperature atmospheric pressure plasma plume for biomedical applications
Mounir Laroussi,Xinpei Lu +1 more
TL;DR: In this paper, the authors present a device that is capable of generating a cold plasma plume several centimeters in length and exhibits low power requirements as shown by its currentvoltage characteristics.
Journal ArticleDOI
Plasma needle: a non-destructive atmospheric plasma source for fine surface treatment of (bio)materials
TL;DR: In this paper, a non-thermal plasma source (plasma needle) generated under atmospheric pressure by means of radiofrequency excitation has been characterized, which can be applied on organic materials, also in watery environment, without causing thermal/electric damage to the surface.