Colorectal cancer screening: Recommendations for physicians and patients from the U.S. Multi-Society Task Force on Colorectal Cancer.
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"Colorectal cancer screening: Recomm..." refers background in this paper
...To accomplish both aims, tests need to detect early-stage (ie, curable) CRCs and high-risk precancerous lesions.1,21 Detection and removal of precancerous lesions prevents CRC.30,31 The 2 main classes of precancerous lesions in the colon are conventional adenomas and serrated class lesions (Table 2)....
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...Reductions in incidence and mortality are approximately 80% in the distal colon and 40% to 60% in the proximal colon, at least in the www.giejournal.org United States and Germany.57,59,61,62,64 Furthermore, indirect evidence from randomized trials of fecal occult blood testing65 and sigmoidoscopy,66 as well as studies showing highly variable cancer protection provided by different colonoscopists,67,68 also supports a protective effect of colonoscopy against CRC....
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...One or 2 negative examinations may signal lifetime protection against CRC.54 Patients who value the highest level of sensitivity in detection of precancerous lesions and are willing to undergo invasive screening should consider choosing colonoscopy....
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...Detection and removal of precancerous lesions prevents CRC.(30,31) The 2 main classes of precancerous lesions in the colon are conventional adenomas and serrated class lesions (Table 2)....
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