Combating mosquito-borne diseases using genetic control technologies.
Guan-Hong Wang,Guan-Hong Wang,Stephanie Gamez,Robyn R. Raban,John M. Marshall,Luke Alphey,Ming Li,Jason L. Rasgon,Omar S. Akbari +8 more
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TLDR
A review of the latest developments, notable similarities, and critical distinctions between these promising technologies and discuss their future applications for mosquito-borne disease control can be found in this paper, where the authors discuss the future applications of these technologies.Abstract:
Mosquito-borne diseases, such as dengue and malaria, pose significant global health burdens. Unfortunately, current control methods based on insecticides and environmental maintenance have fallen short of eliminating the disease burden. Scalable, deployable, genetic-based solutions are sought to reduce the transmission risk of these diseases. Pathogen-blocking Wolbachia bacteria, or genome engineering-based mosquito control strategies including gene drives have been developed to address these problems, both requiring the release of modified mosquitoes into the environment. Here, we review the latest developments, notable similarities, and critical distinctions between these promising technologies and discuss their future applications for mosquito-borne disease control.read more
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Symbionts and gene drive: two strategies to combat vector-borne disease.
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A decade of stability for wMel Wolbachia in natural Aedes aegypti populations
TL;DR: This paper used a combination of field surveys, phenotypic assessments, and Wolbachia genome sequencing to show that wMel has remained stable in its effects for up to a decade in Australian Ae. aegypti populations.
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Mosquito transgenesis for malaria control
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Mosquito transgenesis for malaria control
TL;DR: In this paper , the authors review the development of transgenesis and its application for malaria control, highlighting the transgenic expression of antiparasitic effector genes, inactivation of host factor genes, and manipulation of miRNAs and lncRNAs.
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Vector-Borne Viral Diseases as a Current Threat for Human and Animal Health—One Health Perspective
TL;DR: A review on arbovirus transmission, ecology, and methods of prevention can be found in this paper , where the authors discuss the current knowledge on ARV transmission and its major vectors: mosquitoes, ticks, biting midges, and sandflies.
References
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Journal ArticleDOI
Wolbachia: master manipulators of invertebrate biology.
TL;DR: The basic biology of Wolbachia is reviewed, with emphasis on recent advances in the authors' understanding of these fascinating endosymbionts, which are found in arthropods and nematodes.
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A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae
Andrew Hammond,Roberto Galizi,Kyros Kyrou,Alekos Simoni,Carla Siniscalchi,Dimitris Katsanos,Matthew Gribble,Dean A. Baker,Eric Marois,Steven Russell,Austin Burt,Nikolai Windbichler,Andrea Crisanti,Tony Nolan +13 more
TL;DR: Population modeling and cage experiments indicate that a CRISPR-Cas9 construct targeting one of these loci meets the minimum requirement for a gene drive targeting female reproduction in an insect population, which could expedite the development of gene drives to suppress mosquito populations to levels that do not support malaria transmission.
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Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi
Valentino M. Gantz,Nijole Jasinskiene,Olga Tatarenkova,Aniko Fazekas,Vanessa M. Macias,Ethan Bier,Anthony A. James +6 more
TL;DR: A highly effective autonomous Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated protein 9 (Cas9)-mediated gene-drive system in the Asian malaria vector Anopheles stephensi, adapted from the mutagenic chain reaction (MCR).
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A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes
Kyros Kyrou,Andrew Hammond,Roberto Galizi,Nace Kranjc,Austin Burt,Andrea Beaghton,Tony Nolan,Andrea Crisanti +7 more
TL;DR: It is found that CRISPR–Cas9-targeted disruption of the intron 4–exon 5 boundary aimed at blocking the formation of functional AgdsxF did not affect male development or fertility, whereas females homozygous for the disrupted allele showed an intersex phenotype and complete sterility.
Journal ArticleDOI
Wolbachia Blocks Currently Circulating Zika Virus Isolates in Brazilian Aedes aegypti Mosquitoes
Heverton Leandro Carneiro Dutra,Marcele Neves Rocha,Fernando Braga Stehling Dias,Simone Brutman Mansur,Eric P. Caragata,Luciano Andrade Moreira +5 more
TL;DR: It is reported that Aedes aegypti harboring Wolbachia are highly resistant to infection with two currently circulating Zika virus isolates from the recent Brazilian epidemic and should be included as part of Zika control strategies.