Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening.
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Cites background or methods from "Combination of high-fat diet-fed an..."
...metabolic characteristics of human type 2 diabetes [1, 2, 4]....
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...Therefore, investigators have started to develop a rat model by high-fat diet following low-dose STZ that would closely mimic the natural history of the disease [1, 2, 4]....
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...At the same time, low-dose STZ has been known to induce a mild impairment of insulin secretion which is similar to the feature of the later stage of type 2 diabetes [1, 2]....
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...the successful rate of this method has not been reported [2]....
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...Although high-dose STZ severely impairs insulin secretion mimicking type 1 diabetes, low-dose STZ has been known to induce a mild impairment of insulin secretion which is similar to the feature of the later stage of type 2 diabetes [1, 2]....
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Additional excerpts
...els of diabetes mellitus [27–31]....
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Cites result from "Combination of high-fat diet-fed an..."
...Previous reports [42–44] have also confirmed that miR144 and IRS1 are expressed in HeLa cells....
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...Combination of high-fat diet and low dose of STZ injection has been widely used to induce T2D in rats and proven to effectively induce T2D whereby the pattern of disease onset and development appears to be closely analogous to that in the human syndrome [43–45]....
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References
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