Journal ArticleDOI
Combinatorial rosamine library and application to in vivo glutathione probe.
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TLDR
A highly selective library member toward reduced glutathione (GSH) was discovered, demonstrating the capability of in vivo GSH level sensing in live cells.Abstract:
Combinatorial approach on fluorescent rosamine library was developed using solid-phase chemistry. A highly selective library member (H22) toward reduced glutathione (GSH) was discovered, demonstrating the capability of in vivo GSH level sensing in live cells.read more
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Fluorescent and colorimetric probes for detection of thiols
TL;DR: This critical review focuses on the fluorescent or colorimetric sensors for thiols according to their unique mechanisms between sensors andThiols, including Michael addition, cyclization with aldehyde, cleavage of sulfonamide and sulfonate ester by thiol s, and metal complexes-oxidation-reduction,Metal complexes-displace coordination, nano-particles and others.
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Intracellular glutathione detection using MnO2-nanosheet-modified upconversion nanoparticles
TL;DR: The ability to monitor the glutathione concentration intracellularly may enable rational design of a convenient platform for targeted drug and gene delivery.
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Combinatorial Strategies in Fluorescent Probe Development
TL;DR: This poster presents a poster presented at the 2016 Singapore International Conference of the American Association for the Advancement of Science and Technology (A*STAR) entitled “Advances in Bioimaging Probe Development: Foundations of a scalable, scalable and reproducible Nanofiltration Probe for Matrix-based Assays.”
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A Palette of Fluorescent Probes with Varying Emission Colors for Imaging Hydrogen Peroxide Signaling in Living Cells
TL;DR: When macrophages labeled with both PO1 and APF were stimulated to induce an immune response, they discovered three distinct types of phagosomes: those that generated mainly hROS, those that produced mainly H(2)O(2), and those that possessed both types of ROS.
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A highly selective ratiometric near-infrared fluorescent cyanine sensor for cysteine with remarkable shift and its application in bioimaging
TL;DR: For the first time, the novel strategy that reversibly modulates the polymethine π-electron system by conjugation and removal of the specific trigger moiety was implemented for the generation of a ratiometric cyanine-based sensor.
References
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Journal ArticleDOI
Signaling Recognition Events with Fluorescent Sensors and Switches.
A. Prasanna de Silva,H. Q. Nimal Gunaratne,Thorfinnur Gunnlaugsson,Allen J. M. Huxley,Colin P. McCoy,Jude T. Rademacher,Terence E. Rice +6 more
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Neuroprotection by the Metabolic Antioxidant α-Lipoic Acid
TL;DR: It is proposed that the various metabolic antioxidant properties of alpha-lipoate relate to its possible therapeutic roles in a variety of brain and neuronal tissue pathologies: thiols are central to antioxidant defense in brain and other tissues.
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Evolution of Fluorescein as a Platform for Finely Tunable Fluorescence Probes
TL;DR: By breaking out of the traditional structure of fluorescein, the first and totally rational design strategy for novel fluorescence probes based on a strict photochemical basis is developed and is exemplified by its application to develop a novel, highly sensitive, and membrane-permeable fluorescence probe for beta-galactosidase, which is the most widely used reporter enzyme.
Journal ArticleDOI
2,4-Dinitrobenzenesulfonyl fluoresceins as fluorescent alternatives to Ellman's reagent in thiol-quantification enzyme assays.
TL;DR: Recently, the use of a dioxetane-disulfide derivative as a chemiluminescent probe in place of DTNB led to an improved sensitivity of the AChE assay with acetylthiocholine (ASCh) by a factor of ten.