Commitment to a cellular transition precedes genome-wide transcriptional change
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Cites background from "Commitment to a cellular transition..."
...Despite co-regulation, the transcription of the regulon through the mitotic cell cycle is temporally organized: the G1 cyclin CLN1 is the earliest activated gene (CLN2 is also relatively early) implying that G1 cyclin positive feedback is initiated prior to genome-wide changes to the transcriptional program [122]....
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228 citations
Cites background from "Commitment to a cellular transition..."
...Whereas SBF activates transcription of Cln cyclins (Nasmyth and Dirick 1991; Spellman et al. 1998; Eser et al. 2011), MBF promotes transcription of Clb5 along with other replication genes (Lowndes et al. 1992; Koch et al. 1993; Spellman et al. 1998; Eser et al. 2011)....
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139 citations
Cites background from "Commitment to a cellular transition..."
...After a simple subtraction, the Whi5-GFP signal does not interfere with the CLN2pr-GFP signal, and vice versa (Skotheim et al., 2008)....
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...In a related paper appearing in this issue, we show that increased expression of the G1 cyclins CLN1 and CLN2 precedes activation of the bulk of the >200 coregulated genes, implying that genomewide changes in transcription depend on cell cycle commitment (Eser et al., 2011)....
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138 citations
References
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"Commitment to a cellular transition..." refers background in this paper
...We analyzed protein accumulation in ten strains expressing C-terminal GFP fusion proteins from the endogenous loci (Ghaemmaghami et al., 2003) and two strains containing an integrated CLN1 or CLN2 promoter driving the expression of a destabilized VenusPEST (Mateus and Avery 2000)....
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3,117 citations
3,048 citations
"Commitment to a cellular transition..." refers background in this paper
...Checkpoints use designated regulatory molecules to restrain cell-cycle progression until a set of criteria are satisfied (Hartwell and Weinert 1989)....
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2,232 citations
"Commitment to a cellular transition..." refers background in this paper
...This extensive oscillation entails 10%–20% of all Caulobacter and budding-yeast genes (Cho et al., 1998; Spellman et al., 1998; Laub et al., 2000)....
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