Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
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Cites background from "Common variants at MS4A4/MS4A6E, CD..."
...In addition to the autosomal dominant PSEN-1, PSEN-2, and APP gene mutations, or 34 allele of apolipoprotein E, which clearly have a major impact on the accumulation of both plaques and CAA in AD, numerous other genetic variations [101,102] and environmental risk factors [103–105] have recently been described; the extent to which these impact the neuropathologic changes of AD remains largely unknown....
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Cites background from "Common variants at MS4A4/MS4A6E, CD..."
...In addition to the autosomal dominant PSEN-1, PSEN-2, and APP gene mutations, or 34 allele of apolipoprotein E, which clearly have a major impact on the accumulation of both plaques and CAA in AD, numerous other genetic variations [101,102] and environmental risk factors [103–105] have recently been described; the extent to which these impact the neuropathologic changes of AD remains largely unknown....
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References
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