Communication by Extracellular Vesicles: Where We Are and Where We Need to Go.
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"Communication by Extracellular Vesi..." refers methods in this paper
...However, we now know that the most popular exosome purification protocols used historically in the literature (differential ultracentrifugation, 220 nm filtration [Thery et al., 2006])—and the recently released commercial kits—co-isolate different types of EVs....
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"Communication by Extracellular Vesi..." refers background in this paper
...Interestingly, sEVs from different tumor types bear integrins (ITGs) that target these sEVs to specific organs and trigger signaling pathways, thereby initiating pre-metastatic niche formation (Hoshino et al., 2015)....
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...For example, sEVs expressing ITGavb5 bind specifically to Kupffer cells, mediating liver tropism, while ITGa6b4 and ITGa6b1 on sEVs bind to lung-resident fibroblasts and epithelial cells, leading to lung tropism (Hoshino et al., 2015)....
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...(Peinado et al., 2012; Zhou et al., 2014) or by conditioning pre-metastatic sites in distant organs (Costa-Silva et al., 2015; Hoshino et al., 2015; Peinado et al., 2012)....
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..., 2014) or by conditioning pre-metastatic sites in distant organs (Costa-Silva et al., 2015; Hoshino et al., 2015; Peinado et al., 2012)....
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3,321 citations
"Communication by Extracellular Vesi..." refers background in this paper
...Cells can secrete different types of EVs that have been classified according to their sub-cellular origin (Colombo et al., 2014)....
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3,076 citations
"Communication by Extracellular Vesi..." refers background in this paper
...Loss of the protein also decreases EV-independent secretion of soluble factors, such as some growth factors and metalloproteinases that are also involved in tumor metastasis (Bobrie et al., 2012; Peinado et al., 2012)....
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...Consistently, knocking down RAB27A in melanoma (Peinado et al., 2012), breast (Bobrie et al., 2012), fibrosarcoma (Sung et al., 2015), or prostate cancer cell lines (Webber et al., 2015) reduces the secretion of sEVs....
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..., 2014) or by conditioning pre-metastatic sites in distant organs (Costa-Silva et al., 2015; Hoshino et al., 2015; Peinado et al., 2012)....
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...Lower incidence of metastasis was also observed (Bobrie et al., 2012; Peinado et al., 2012)....
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...…melanoma tumor sEVs bearing a tyrosine-kinase receptor can promote migration of bone marrow progenitor cells to future sites of metastasis, whereas sEVs secreted by a less-aggressive version of the same tumor, devoid of the relevant receptor, do not display this effect (Peinado et al., 2012)....
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