Journal ArticleDOI
Comparative effects of smoking marihuana or placebo on human motor and mental performance.
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TLDR
A significant decrement in all motor performance tests and in five of nine mental performance tests was observed after the marihuana cigarette, and the authors were not able to detect any cannabinols in the blood or urine of subjects who smoked the marhuana.Abstract:
Motor and mental performance was tested after smoking a placebo cigarette and after smoking a marihuana cigarette calibrated to deliver 5 mg. of delta‐9‐tetrahydrocannabinol. A significant decrement in all motor performance tests and in five of nine mental performance tests was observed after the marihuana cigarette. We were not able to detect any cannabinols in the blood or urine of subjects who smoked the marihuana.read more
Citations
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Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study
TL;DR: The results suggest that the presently characterized cannabinoid receptor mediates physiological and behavioral effects of natural and synthetic cannabinoids, because it is strongly coupled to guanine nucleotide regulatory proteins and is discretely localized to cortical, basal ganglia, and cerebellar structures involved with cognition and movement.
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Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain.
TL;DR: The anatomical distribution and density of cannabinoid receptors in the human brain was studied in one fetal, two neonatal and eight adult human cases using quantitative receptor autoradiography following in vitro labelling of sections with the synthetic cannabinoid agonist [3H]CP55,940.
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Cannabis and the brain
TL;DR: Central effects of cannabinoids include disruption of psychomotor behaviour, short-term memory impairment, intoxication, stimulation of appetite, antinociceptive actions (particularly against pain of neuropathic origin) and anti-emetic effects.
Journal ArticleDOI
A comparison of mainstream and sidestream marijuana and tobacco cigarette smoke produced under two machine smoking conditions.
David Moir,William S. Rickert,Genevieve Levasseur,Yolande Larose,Rebecca M. Maertens,Paul D. White,Suzanne Desjardins +6 more
TL;DR: Mainstream marijuana smoke contained selected polycyclic aromatic hydrocarbons at concentrations lower than those found in mainstream tobacco smoke, while the reverse was the case for sidestream smoke, with PAHs present at higher concentrations in marijuana smoke.
Journal ArticleDOI
Evaluation of a vaporizing device (Volcano) for the pulmonary administration of tetrahydrocannabinol.
TL;DR: Evaluating the performance of the Volcano vaporizer in terms of reproducible delivery of the bioactive cannabinoid tetrahydrocannabinol (THC) by using pure cannabinoid preparations, shows that with the Volcano a safe and effective cannabinoid delivery system seems to be available to patients.
References
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Journal ArticleDOI
Clinical and Psychological Effects of Marihuana in Man
TL;DR: The primitive state of knowledge of the drug, the research problems encountered in designing a replicable study, and the results of the investigations are described.
Journal ArticleDOI
Comparison of tetrahydrocannabinol and synhexyl in man
TL;DR: These drugs differed from LSD in the following respects: sedation was prominent; euphoria was langer lasting; dreamlike sequences more pronounced; and physiological and biochemical effects were somewhat different, especially in the absence of sympathomimetic effects.
Journal ArticleDOI
Iii. comparison of the effects of marijuana and alcohol on simulated driving performance
TL;DR: This paper studied simulated driving performance of a group of adults who were experienced marijuana smokers, familiar with the effects of alcohol, who were licensed motor vehicle operators, and were engaged in educational or vocational pursuit.
Journal ArticleDOI
Acute effects of marihuana on speech.
Andrew Weil,Norman E. Zinberg +1 more
TL;DR: Persons high on marihuana have subtle difficulties in speech, primarily in remembering from moment to moment the logical thread of what is being said.