Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma
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...Specific characteristics have been proposed for these subgroups of EVs in some instances, but currently there is still a lack of widely accepted specific markers to distinguish these populations (26,27)....
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Cites methods from "Comparative proteomics evaluation o..."
...techniques have been carried out (6,13,20), but there is...
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...pure exosome preparation from plasma (13); however,...
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...Density gradient purification is a technique repeatedly shown to provide the highest degree of purity (6,12,13)....
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"Comparative proteomics evaluation o..." refers background or result in this paper
...This observation is consistent with the buoyant density of exosomes reported in previous studies [3, 12, 27, 30]....
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...Exosomes harbor proteins, RNA, and lipids representing a subproteome of the cell of origin [1,3,5] and are also identified in various biological fluids including blood, urine, amniotic fluid, saliva, malignant ascites, synovial fluid, and breast milk [5–9]....
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4,380 citations
"Comparative proteomics evaluation o..." refers background in this paper
...Exosomes harbor proteins, RNA, and lipids representing a subproteome of the cell of origin [1,3,5] and are also identified in various biological fluids including blood, urine, amniotic fluid, saliva, malignant ascites, synovial fluid, and breast milk [5–9]....
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"Comparative proteomics evaluation o..." refers background in this paper
...While exosomes are implicated in a variety of biological functions including intercellular communication, recent studies have highlighted important applications of exosomes as a source of disease biomarkers [10–12] and as drug delivery vehicles [5, 13, 14]....
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...The recent finding that exosomes can cross the blood–brain barrier and be used as targeted drug delivery vehicles has gained significant attention as exosomes have low immunogenicity compared with liposomes and virus-based drug delivery systems [13, 14]....
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