Comparative Study of Antidiabetic Activity of Hexane-Extract of Lemon Peel (Limon citrus) and Glimepiride in Alloxan-Induced Diabetic Rats
TL;DR: It was found that the hexane extract of lemon peel showed antidi diabetic activity comparable to that of glimepiride, and it can thus be inferred that the extract of Lemon peel possesses significant antidiabetic activity.
Abstract: Diabetes is classified as a metabolic disorder manifested by elevated level of glucose in the blood. An attempt has been made to compare the antidiabetic activity of hexane extract of lemon peel (Citrus Limon ) with that of a marketed product, glimepiride, in alloxan-induced diabetic rats. The study was performed by the measurement of blood glucose level using a glucometer. It was found that the hexane extract of lemon peel showed antidiabetic activity comparable to that of glimepiride. It can thus be inferred that the extract of lemon peel possesses significant antidiabetic activity. DOI: http://dx.doi.org/10.3329/bpj.v15i2.12577 Bangladesh Pharmaceutical Journal 15 (2): 131-134, 2012
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TL;DR: Peels from citrus fruits can be used as sources of functional compounds and preservatives for the development of newer food products, that are not only safe but also have health-promoting activities.
240 citations
TL;DR: The potential of these plants as natural alternative treatments of some metabolic alterations associated with obesity are considered, and mechanisms of action of diverse plants such as Camellia sinensis, Hibiscus sabdariffa, Hypericum perforatum, Persea americana, Phaseolus vulgaris, Capsicum annuum and Rosmarinus officinalis are considered.
Abstract: Obesity is the most prevalent nutritional disease and a growing public health problem worldwide. This disease is a causal component of the metabolic syndrome related with abnormalities, including hyperglycemia, dyslipidemia, hypertension, inflammation, among others. There are anti-obesity drugs, affecting the fundamental processes of the weight regulation; however they have shown serious side effects, which outweigh their beneficial effects. Most recent studies on the treatment of obesity and its complications have focused on the potential role of different plants preparation that can exert a positive effect on the mechanisms involved in this pathology. For instance, anti-obesity effects of green tea and its isolated active principles have been reported in both in vitro (cell cultures) and in vivo (animal models) that possess healthy effects, decreasing adipose tissue through reduction of adipocytes differentiation and proliferation. A positive effect in lipid profile, and lipid and carbohydrates metabolisms were demonstrated as well. In addition, anti-inflammatory and antioxidant activities were studied. However, the consumption of green tea and its products is not that common in Western countries, where other plants with similar bioactivity predominate; nevertheless, the effect extension has not been analyzed in depth, despite of their potential as alternative treatment for obesity. In this review the anti-obesity potential and reported mechanisms of action of diverse plants such as: Camellia sinensis, Hibiscus sabdariffa, Hypericum perforatum, Persea americana, Phaseolus vulgaris, Capsicum annuum, Rosmarinus officinalis, Ilex paraguariensis, Citrus paradisi, Citrus limon, Punica granatum, Aloe vera, Taraxacum officinale and Arachis hypogaea is summarized. We consider the potential of these plants as natural alternative treatments of some metabolic alterations associated with obesity.
86 citations
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...Similarly, Naim et al. (2012) reported that hexane extracts from lemon peels showed antidiabetic activity in alloxaninduced diabetic rats, detecting reduced blood glucose level of 44.57, 75.96, 95.43, and 98.08 % in 24, 48, 72, and 96 h, respectively, compared with counterpart controls....
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TL;DR: The Sol-PEG polymeric hybrids represent a promising tool for enhanced delivery of glimepiride and were found to be stable over a period of 6 months with no significant changes in the drug content.
42 citations
TL;DR: It is proposed that oral administration of citrus peel extracts has a therapeutic potential in the treatment of chronic wounds in diabetes by reducing blood glucose and time to wound closure.
Abstract: Diabetic patients wound healing is slower than the healthy individuals Three citrus peel extracts; Lemon (Citrus limon), Grapes fruits (Citrus paradise) and Orange (Citrus sinensis) promote wound healing in experimental animals This study investigated the effect of oral treatment with citrus peel extracts on wound repair of the skin of diabetic rats The extracts were estimated for vitamin C and total carotenoid contents prior to animal study Diabetes mellitus was induced in rats by intraperitoneal injection of a single dose of streptozotocin (STZ, 75 mg kg(-1) bwt) One week after diabetes induction, full thickness excision wounds were made in hyperglycemic rats and were divided groups, each containing 6 rats The different test group animals were treated with different citrus peel extract orally at the dose of 400 mg kg(-1) body weight daily for 12 days The blood glucose, body weight and rate of wound closure of each rat were measured every 3rd day during the experimental period At the end of experiment, granular tissues of wounds were removed and estimated for hydroxylproline and total protein content The results showed significant reduction in blood glucose and time to wound closure Tissue growth and collagen synthesis were significantly higher as determined by total protein and hydroxyl proline content From our experimental data, we propose that oral administration of citrus peel extracts has a therapeutic potential in the treatment of chronic wounds in diabetes
28 citations
TL;DR: Certain species having higher priority indices for further phytochemical investigation are highlighted in the present study in order to smooth continuation and extension of traditional medical knowledge and practice for ensuring safe and effective therapy.
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TL;DR: The results indicate that the CHCl3-CC fraction is relatively more potent than other fractions of C. cordifolia and the PET-CR is found to be better than other fraction of catharanthus.
Abstract: The aim of this study is to investigate the hypoglycemic effects of petroleum ether, chloroform and ethyl acetate fractions isolated from ethanolic extracts of Coccinia cordifolia and Catharanthus roseus on normal control and orally glucose-induced hyperglycemic rats. Single doses (150 mg/kg) of different fractions of C. cordifolia and C. roseus extracts were intraperitonelly administered. The serum blood glucose level was obtained by pricking the tail vein using glucometer at time 0, 30, 60, 90, 150 and 270 minutes. In the orally glucose induced hyperglycemic rats, chloroform-coccinia (CHCl3-CC) fraction showed maximum reduction of blood glucose level by 21.94% on 60 minute of the experiment. On the other hand maximum reduction (p<0.05) of 17.92% was observed for petroleum ether-catharanthus (PET-CR) on 30 minute of the experiment. Metformin HCl was used as standard drug. Our results indicate that the CHCl3-CC fraction is relatively more potent than other fractions of C. cordifolia. Similarly the PET-CR is found to be better than other fractions of catharanthus. Phytochemical screening test results showed that chloroform fraction of C. cordifolia contain saponins and flavonoids compounds, which are known to be hypoglycemic. On the other hand petroleum ether fraction of C. roseus contains tannins, flavonoids and alkaloid compounds produced varying degree of blood sugar reduction. On the pharmacological point of view C. cordifolia and C. roseus appears to be a valuable plant, which can be useful, at least as an adjunct, in the therapy of diabetes.
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TL;DR: It was found that the hypoglycemic activities of both gliclazide and metformin HCl were potentiated by concurrent application of caffeine and either of the drugs, but the extent of potentiation was more in case of met formin HCI as evident from the blood sugar level of rats.
Abstract: An in vivo study has been conducted to observe the effects of caffeine on the hypoglycemic activity of gliclazide and metformin HCI in rats. For this, healthy rats weighing about 250±25 g were used and the blood sugar levels were measured after administration of a drug alone and in combination. Diabetes was induced in rats by administration of alloxan at a dose of 40 mg/kg body weight. Drugs were administered in rats and were observed for four weeks. The blood sugar levels were estimated in two stages; firstly, after two week and secondly, after four week of administration of drug. It was found that the hypoglycemic activities of both gliclazide and metformin HCl were potentiated by concurrent application of caffeine and either of the drugs, but the extent of potentiation was more in case of metformin HCI as evident from the blood sugar level of rats. Key words: Caffeine; Gliclazide; Metformin; Diabetes; Alloxan; Blood sugar; Rats. DOI: 10.3329/dujps.v8i1.5335 Dhaka Univ. J. Pharm. Sci. 8(1): 47-51, 2009 (June)
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