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Journal Article

Comparison of experimental tuberculosis in cortisone-treated and alloxan-diabetic albino rats.

01 May 1952-American review of tuberculosis (National Tuberculosis Association)-Vol. 65, Iss: 5, pp 602
About: This article is published in American review of tuberculosis.The article was published on 1952-05-01 and is currently open access. It has received 6 citations till now. The article focuses on the topics: Alloxan & Tuberculosis.
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Journal ArticleDOI
TL;DR: It is, therefore, particularly important to conduct vigorous tuberculosis case-finding efforts among diabetics, not only for their own good but to avert the maintenance of a reservoir of tuberculous infection among diabetic men similar to that currently existing among older men.

23 citations

Journal ArticleDOI
TL;DR: The combination of steroid treatment with effective antituberculosis chemotherapy gives excellent results in certain selected cases and the deleterious effect of steroid Treatment on tuberculous lesions has also been observed.
Abstract: THE ADVERSE effect of corticosteroids has been demonstrated experimentally in tuberculous animals. 7,20,28,30,44 However, the dosage in these experiments was high, about ten times the amount currently used in human beings. Other experiments, in which there was a smaller dose of steroids associated with specific antituberculosis drugs have demonstrated the favorable effect of hormonotherapy on exudative lesions in laboratory animals. 2,4,33 In tuberculous lymph nodes, steroids reduce both necrosis and the formation of epithelioid cells and exert an inhibitory effect on fibrosis. 24 In clinical medicine, the deleterious effect of steroid treatment on tuberculous lesions has also been observed, 4,10 but here also the combination of steroid treatment with effective antituberculosis chemotherapy gives excellent results in certain selected cases. 1,5,9 It was first claimed to be effective in pleural effusions 40 and the claim then extended to some other forms of human tuberculosis. 3 Favorable effects were confirmed by pathologic

14 citations

Journal ArticleDOI
TL;DR: Untreated diabetic animals infected for 14 days begin to form cortical abscesses, demonstrating that the sequence of events in the inflammatory response which leads to abscess formation in the nondiabetic rat is markedly delayed in the untreated diabetic animal unless insulin therapy is given.

6 citations