Comparison of Ipragliflozin and Pioglitazone Effects on Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes: A Randomized, 24-Week, Open-Label, Active-Controlled Trial
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Cites background from "Comparison of Ipragliflozin and Pio..."
...In two recent open-label studies,(38,39) investigators reported a significant decrease in the liver-to-spleen attenuation ratio in patients with T2DM treated for 6 months with luseogliflozin or ipragliflozin, respectively....
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...• N ei th er o f t he R CT s ( 39 ,4 1) w as p la ce bo -c on tro lle d, a nd p ar tic ip an ts w er e co nc ur re nt ly ta ki ng o th er m ed ic at io ns th at c ou ld h av e po te nt ia lly im pa ct ed o ut co m es ....
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...( 39 ) RC T (o pe n la be l): p at ie nt s w ith N AF LD a nd T 2D M...
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230 citations
References
7,705 citations
"Comparison of Ipragliflozin and Pio..." refers background in this paper
...They have also reportedly shownpleiotropic effects on various complications and regulatory effects on macrovascular events (8,9) as well as beneficial effects on hepatic dysfunction in both clinical trials and animal models (10–12)....
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3,429 citations
"Comparison of Ipragliflozin and Pio..." refers background in this paper
...Nonalcoholic fatty liver disease (NAFLD) is a broad disease concept that ranges from nonalcoholic fatty liver, which refers to steatosis affecting hepatocytes, to nonalcoholic steatohepatitis (NASH), the inflammationand fibrosis that occur in addition to steatosis and may result in hepatic cirrhosis and hepatocellular carcinoma (1)....
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2,632 citations
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"Comparison of Ipragliflozin and Pio..." refers methods in this paper
...We also determined the NAFLD fibrosis score (14), fibrosis 4 (FIB4) index (15), and NAFIC (NASH, ferritin, IRI, and type IV collagen 7S) score (16) at the start of the trial and after 24 weeks as noninvasive screening for NASH progression....
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1,910 citations
"Comparison of Ipragliflozin and Pio..." refers background in this paper
...The frequency of NAFLD continues to increase worldwide, and its prevalence in Western countries has grown to ;20–40% (3)....
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