Comparison of the Elecsys Anti-SARS-CoV-2 immunoassay with the EDI™ enzyme linked immunosorbent assays for the detection of SARS-CoV-2 antibodies in human plasma.
Margot Egger,Christian Bundschuh,Kurt Wiesinger,Christian Gabriel,Martin Clodi,Thomas Mueller,Benjamin Dieplinger +6 more
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TLDR
A head-to-head comparison of the fully-automated Elecsys® Anti-SARS-CoV-2 immunoassay with the EDITM enzyme linked immunosorbent assays (ELISA) for the detection of SARS- CoV- 2 antibodies in human plasma indicates a high sensitivity and specificity for the ElecsYS® assay and an acceptable agreement with the EditorialM ELISAs.About:
This article is published in Clinica Chimica Acta.The article was published on 2020-10-01 and is currently open access. It has received 99 citations till now. The article focuses on the topics: Immunoassay.read more
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COVID-19: a review
TL;DR: This review of the COVID-19 pandemic aims to offer a comprehensive and thorough explanation of the disease, including its significance and impact on surgery, by drawing information from the most up to date and relevant sources available.
Journal ArticleDOI
Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19:Serologic Testing.
Kimberly E. Hanson,Angela M. Caliendo,Cesar A. Arias,Janet A. Englund,Mary K. Hayden,Mark J Lee,Mark Loeb,Robin Patel,Osama Altayar,Abdallah El Alayli,Shahnaz Sultan,Yngve Falck-Ytter,Valery Lavergne,Rebecca L. Morgan,M. Hassan Murad,Adarsh Bhimraj,Reem A. Mustafa +16 more
TL;DR: This guideline highlights important unmet research needs pertaining to the use of anti-SARS-CoV-2 antibody tests for diagnosis, public health surveillance, vaccine development and the selection of convalescent plasma donors.
Journal ArticleDOI
SARS-CoV-2-IgG response is different in COVID-19 outpatients and asymptomatic contact persons.
Nele Wellinghausen,Dietmar Plonné,Meike Voss,Ralitsa Ivanova,Reinhard Frodl,Susanne Deininger +5 more
TL;DR: Serological response to SARS-CoV-2 in outpatients including asymptomatic persons is less pronounced than in hospitalized patients, and a lower viral load is suggested as a possible explanation for lower rate of seropositivity.
Journal ArticleDOI
A comparative review of immunoassays for COVID-19 detection.
TL;DR: A literature review on the databases of PubMed, Scopus and Google Scholar between January 1, 2020 and June 30, 2020 based on the main serological methods for COVID-19 detection with the focus on comparative experiments was performed as discussed by the authors.
Journal ArticleDOI
Comparison of eight commercial, high-throughput, automated or ELISA assays detecting SARS-CoV-2 IgG or total antibody.
TL;DR: Compared the performance of assays detecting IgG or total antibodies to N or S antigens, validated for routine use in France, with samples from subjects with more or less severe SARS-CoV-2 infection, discrepancies occurred, without a systematic origin.
References
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Victor M. Corman,Olfert Landt,Marco Kaiser,Richard Molenkamp,Adam Meijer,Daniel K.W. Chu,Tobias Bleicker,Sebastian Brünink,Julia Schneider,Marie Luisa Schmidt,Daphne G.J.C. Mulders,Bart L. Haagmans,Bas van der Veer,Sharon van den Brink,Lisa Wijsman,Gabriel Goderski,Jean Louis Romette,Joanna Ellis,Maria Zambon,Malik Peiris,Herman Goossens,Chantal B.E.M. Reusken,Marion Koopmans,Christian Drosten +23 more
TL;DR: A validated diagnostic workflow for 2019-nCoV is presented, its design relying on close genetic relatedness of 2019- nCoV with SARS coronavirus, making use of synthetic nucleic acid technology.
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TL;DR: It is suggested that SARS-CoV2-specific IgG or IgM seroconversion occurs within 20 days post symptom onset and may be helpful for the diagnosis of suspected patients with negative RT–PCR results and for the identification of asymptomatic infections.
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TL;DR: The findings provide strong empirical support for the routine application of serological testing in the diagnosis and management of COVID-19 patients and offer vital clinical information during the course of SARS-CoV-2 infection.
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Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19)
Li Guo,Lili Ren,Siyuan Yang,Meng Xiao,De Chang,Fan Yang,Charles S. Dela Cruz,Yingying Wang,Chao Wu,Yan Xiao,Lulu Zhang,Lianlian Han,Shengyuan Dang,Yan Xu,Qi Wen Yang,Sheng Yong Xu,Hua Dong Zhu,Yingchun Xu,Qi Jin,Lokesh Sharma,Linghang Wang,Jianwei Wang +21 more
TL;DR: The humoral response to SARS-CoV-2 can aid in the diagnosis of COVID-19, including subclinical cases, and the detection efficiency by IgM ELISA is higher than that of qPCR after 5.5 days of symptom onset.
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Molecular Diagnosis of a Novel Coronavirus (2019-nCoV) Causing an Outbreak of Pneumonia.
Daniel K.W. Chu,Yang Pan,Yang Pan,Samuel M.S. Cheng,Kenrie P Y Hui,Pavithra Krishnan,Yingzhi Liu,Daisy Y M Ng,Carrie K C Wan,Peng Yang,Peng Yang,Quanyi Wang,Malik Peiris,Leo L.M. Poon +13 more
TL;DR: Two 1-step quantitative real-time reverse-transcription PCR assays can achieve a rapid detection of 2019n-CoV in human samples, thereby allowing early identification of patients.
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