Journal ArticleDOI
Complex Formation Reactions of Promethazine Copper(II) and Various Biologically Relevant Ligands. Synthesis, Equilibrium Constants, Spectroscopic Characterization and Biological Activity
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In this paper, the ternary complexes of copper(II) involving promethazine, N,N-dimethyl-3-(phenothiazin-10-yl)propylamine (Prom) and various biologically relevant ligands containing different functional groups, were investigated.Abstract:
Binary and ternary complexes of copper(II) involving promethazine, N,N-dimethyl-3-(phenothiazin-10-yl)propylamine (Prom) and various biologically relevant ligands containing different functional groups, were investigated. The ligands (L) are dicarboxylic acids, amino acids, amides and DNA constituents. The ternary complexes of amino acids, dicarboxylic acids or amides are formed by simultaneous reactions. The results showed the formation of Cu(Prom)(L) complexes with amino acids and dicarboxylic acids. The effect of chelate ring size of the dicarboxylic acid complexes on their stability constants was examined. Amides form both Cu(Prom)(L) complexes and the corresponding deprotonated species Cu(Prom)(LH−1). The ternary complexes of copper(II) with (Prom) and DNA are formed in a stepwise process, whereby binding of copper(II) to (Prom) is followed by ligation of the DNA components. DNA constituents form both 1:1 and 1:2 complexes with Cu(Prom)2+. The stability of these ternary complexes was quantitatively compared with their corresponding binary complexes in terms of the parameters Δlog10K. The values of Δlog10K indicate that the ternary complexes containing aromatic amino acids were significantly more stable than the complexes containing alkyl- and hydroxyalkyl-substituted amino acids. The concentration distribution of various complex species formed in solution was also evaluated as a function of pH. The solid complexes [Cu(Prom)L)] where L=1,1-cyclobutanedicarboxylic acid (CBDCA), oxalic and malonic acid were isolated and characterized by elemental analysis, infrared, TGA, and magnetic susceptibility measurements. Spectroscopic studies of the complexes revealed that the complexes exhibits square planar coordination with copper(II). The isolated solid complexes have been screened for their antimicrobial activities using the disc diffusion method against some selected bacteria and fungi. The activity data show that the metal complexes are found to have antibacterial and antifungal activity.read more
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Metal Chelation Therapy and Parkinson’s Disease: A Critical Review on the Thermodynamics of Complex Formation between Relevant Metal Ions and Promising or Established Drugs
Marianna Tosato,Valerio Di Marco +1 more
TL;DR: The present review reports a list of approximately 800 compounds which have been used, tested or proposed for Parkinson’s disease (PD) therapy in the year range 2014–2019 (April), name(s), chemical structure and references are given.
Journal ArticleDOI
Synthesis, Spectra, and Electron-Transfer Reaction of Aspartic Acid-Functionalized Water-Soluble Perylene Bisimide in Aqueous Solution
TL;DR: An aspartic acid-functionalized water-soluble perylene bisimide, N,N'-di(2-succinic acid)-perylene-3,4,9,10-tetracarboxylic bisimides (PASP) was synthesized and characterized and is expected to be used in the water photolysis.
Journal ArticleDOI
Aspartic acid functionalized water-soluble perylene diimide as "Off-On" fluorescent sensor for selective detection Cu(2+) and ATP.
TL;DR: PASP-Cu solution was used as a "turn-on" fluorescence biosensor to detect ATP and its coordinate stoichiometry increased to 7.5 in the same pH in the presence of HEPES buffer.
Journal ArticleDOI
Stability constants of bio-relevant, redox-active metals with amino acids: The challenges of weakly binding ligands
TL;DR: An overview of amino acid stability constants with Cu(I), Cu(II), Fe(II) and Fe(III), the most common redox-active metal ions in biological systems are presented and methods available for stability constant determination are described.
References
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Book
Infrared and Raman Spectra of Inorganic and Coordination Compounds
TL;DR: In this article, the normal modes of vibration are illustrated and corresponding vibrational frequencies are listed for each type, including diatomic, triatomic, fouratomic, five-atomic, six-atomic and seven-atomic types.
Book
Advanced Inorganic Chemistry
TL;DR: Cotton and Wilkinson's Advanced Inorganic Chemistry (AIC) as discussed by the authors is one of the most widely used inorganic chemistry books and has been used for more than a quarter century.
Book
Basic Inorganic Chemistry
TL;DR: The Periodic Table and the Chemistry of the Elements as discussed by the authors are the main sources of information about the transition elements of the periodic table and their relationships with the transition metal complexes with TT-Acceptor (TT-Acid) ligands.