Complexity in cancer biology: is systems biology the answer?
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Cites background from "Complexity in cancer biology: is sy..."
...Many researchers have called for an analytical use of systems biology to transcend the study of individual genes/proteins and to integrate this complexity into higher order phenotypes (500,501)....
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References
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"Complexity in cancer biology: is sy..." refers background in this paper
...The involvement of identified networks must be experimentally confirmed using data from different sources aiming at defining how they render cells (a) immortalized, (b) defective in apoptosis, (c) able to metastasize [63], and (d) their circuitry delineated and critical nodes identified and tested for prevention and therapy [64]....
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"Complexity in cancer biology: is sy..." refers background in this paper
...All these are cross-linked and combined together constitute the cellular network [108]....
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6,672 citations
"Complexity in cancer biology: is sy..." refers background in this paper
...[102] has demonstrated that during tumor growth nearly two thirds of somatic mutations are absent or nondetectable in every tumor region....
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5,878 citations