Comprehensive histologic analysis of ALK-rearranged lung carcinomas.
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...By analyzing the relationship between these data, new clinicopathological relationships, for example, the relationship between the morphological characteristic and the somatic mutation of the cancer, can be found [34,35]....
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"Comprehensive histologic analysis o..." refers background in this paper
...The clinical importance of the molecular subtyping of cancer lies primarily in its therapeutic implications because different subtypes may respond to treatment in a different manner.(10,11) The recent discovery of a fusion gene that joins the echinoderm microtubule-associated protein-like 4 (EML4) gene and the anaplastic lymphoma kinase (ALK) gene in a subset (1% to 5%) of non-small-cell lung carcinomas (NSCLCs) has added another molecular subtype to the classification scheme for lung cancers....
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...For example, epidermal growth factor receptor and KRAS mutations, 2 major genetic changes seen in many adenocarcinomas, now delineate 2 different molecular subtypes characterized by different patient demographics and tumor histologies.(6,10,11,21) The clinical importance of the molecular subtyping of cancer lies primarily in its therapeutic implications because different subtypes may respond to treatment in a different manner....
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"Comprehensive histologic analysis o..." refers methods in this paper
...The IDI is a measure of performance of prediction models based on integrated sensitivity and specificity and had been proven to offer incremental information over the conventional area under the receiver-operatingcharacteristic curve.(12)...
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4,826 citations
"Comprehensive histologic analysis o..." refers background in this paper
...The recent discovery of a fusion gene that joins the echinoderm microtubule-associated protein-like 4 (EML4) gene and the anaplastic lymphoma kinase (ALK) gene in a subset (1% to 5%) of non-small-cell lung carcinomas (NSCLCs) has added another molecular subtype to the classification scheme for lung cancers.(16) The EML4-ALK fusion seems to be formed by a small inversion within the short arm of chromosome 2, and the encoded chimeric protein is dimerized unliganded, leading to constitutive activation....
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4,091 citations
"Comprehensive histologic analysis o..." refers background in this paper
...%) of non-small-cell lung carcinomas (NSCLCs) has added another molecular subtype to the classification scheme for lung cancers.16 The EML4-ALK fusion seems to be formed by a small inversion within the short arm of chromosome 2, and the encoded chimeric protein is dimerized unliganded, leading to constitutive activation.5 To date, numerous fusion variants have been identified, and KIF5B was found to be an additional fusion partner of ALK.17 The importance of recognizing this molecular subtype was highlighted by an international phase I/II clinical trial in which the ALK inhibitor crizotinib (PF02341066) yielded encouraging overall response and disease control rates in a cohort of patients with ALK-rearranged NSCLCs.4 Although researchers agreed that most ALK-rearranged NSCLCs are adenocarcinomas, detailed histomorphologic studies have yielded somewhat conflicting results.1–3,13 Some researchers found that ALK-rearranged NSCLCs exhibited a conspicuous acinar growth pattern and extracellular mucus production.1–3 In contrast, othersCopyright r 2011 by Lippincott Williams & Wilkins From the *Pathology and Clinical Laboratory Division; JDivision of Thoracic Surgery; zDivision of Thoracic Oncology, National Cancer Center Hospital; wDepartment of Pathology, The University of Tokyo; zDivision of Genome Biology; #Division of Cancer Genomics, Center for Medical Genomics, National Cancer Center Research Institute; and yDepartment of Clinical Medicine (Biostatistics), School of Pharmacy, Kitasato University, Tokyo, Japan....
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...1232 | www.ajsp.com r 2011 Lippincott Williams & Wilkins researchers,1–3 and the solid signet-ring cell pattern was reported mainly by the North American investigators.13 We confirmed that both patterns were similarly characteristic of ALK-rearranged NSCLCs....
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...The importance of recognizing this molecular subtype was highlighted by an international phase I/II clinical trial in which the ALK inhibitor crizotinib (PF02341066) yielded encouraging overall response and disease control rates in a cohort of patients with ALK-rearranged NSCLCs.(4) Although researchers agreed that most ALK-rearranged NSCLCs are adenocarcinomas, detailed histomorphologic studies have yielded somewhat conflicting results....
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4,071 citations
"Comprehensive histologic analysis o..." refers background in this paper
...The clinical importance of the molecular subtyping of cancer lies primarily in its therapeutic implications because different subtypes may respond to treatment in a different manner.(10,11) The recent discovery of a fusion gene that joins the echinoderm microtubule-associated protein-like 4 (EML4) gene and the anaplastic lymphoma kinase (ALK) gene in a subset (1% to 5%) of non-small-cell lung carcinomas (NSCLCs) has added another molecular subtype to the classification scheme for lung cancers....
[...]
...For example, epidermal growth factor receptor and KRAS mutations, 2 major genetic changes seen in many adenocarcinomas, now delineate 2 different molecular subtypes characterized by different patient demographics and tumor histologies.(6,10,11,21) The clinical importance of the molecular subtyping of cancer lies primarily in its therapeutic implications because different subtypes may respond to treatment in a different manner....
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