Comprehensive mapping of long-range interactions reveals folding principles of the human genome.
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...In our earlier experiments at 1 Mb map resolution (Lieberman-Aiden et al., 2009), we saw large squares of enhanced contact frequency tiling the diagonal of the contact matrices....
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...C showed strong consistency between our loop calls and all six previously published Hi-C experiments in lymphoblastoid cell lines (Lieberman-Aiden et al., 2009; Kalhor et al., 2012) (Figure 3D; Data S2, I.E; Table S6)....
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...Dilution Hi-C was performed as in Lieberman-Aiden et al. (2009)....
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...(C) We compare our map of chromosome 7 in GM12878 (last column) to earlier Hi-Cmaps: Lieberman-Aiden et al. (2009), Kalhor et al. (2012), and Jin et al. (2013)....
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...To interrogate all loci at once, we developed Hi-C, which combines DNA proximity ligation with high-throughput sequencing in a genome-wide fashion (Lieberman-Aiden et al., 2009)....
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