Computational deconvolution: extracting cell type-specific information from heterogeneous samples.
Citations
6,967 citations
2,040 citations
1,812 citations
Cites background or methods or result from "Computational deconvolution: extrac..."
...These include (1) the ability to customize signature matrices for nearly any tissue type without the need for complicated antibody panels or cell sorting schemes, and (2) the ability to study poorly understood or unknown transcriptional states at scale....
[...]
...highly consistent with those of normal GC and activated B cells and (2) ~9-fold more significant, on average, than in bulk DLBCL tumors (Supplementary Fig....
[...]
...We then compared our results with two alternative methods: (1) a common strategy for assigning bulk tissue expression patterns to individual cell types based on correlations with cell abundance38, and (2) a previously described technique for imputing cell type-specific DEGs when phenotypic classes and cell type frequencies are known25....
[...]
...Given these input files, CIBERSORTx allows (2) imputation of the fractional representations of each cell type present in the mixture, similar to its predecessor....
[...]
1,663 citations
Cites background from "Computational deconvolution: extrac..."
...The deconvolution of these signals can yield estimates of cell population proportions in a sample [8]....
[...]
...MCP-counter is based on the methodological framework [8] of transcriptomic markers (TM), defined as gene expression features expressed in one and only one cell population and whose expression shows little variation within the population of interest (step 1)....
[...]
1,046 citations
References
11,864 citations
"Computational deconvolution: extrac..." refers methods in this paper
...Estimating a condition effect accounting for sample heterogeneity may be performed either at low-resolution, by (c) sample heterogeneity correction [25 ,26,27 ,28 ,29], or at high-resolution, by (d) cell type-specific deconvolution methodologies [25 ,26,30]....
[...]
5,764 citations
4,464 citations
4,128 citations
2,438 citations