Computational Efficiency in Continuous (and Discrete!) Time Models – Comment on Hecht and Zitzmann
References
756 citations
"Computational Efficiency in Continu..." refers methods in this paper
...Such computational differences are, as mentioned, already leveraged in software such as OpenMx (Neale et al., 2016) to maximize performance....
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...In the case that individuals all share the same observation timing pattern, then OpenMx detects that there is no need to re-compute the model expectations, and performance can be very fast, as seen in the results from Hecht and Zitzmann....
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...This approach they favor is actually what is used in the original mixed effects implementation of ctsem (Driver et al., 2017), which used OpenMx to implement CT models using a RAM (McArdle, 2005) formulation of SEM....
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533 citations
"Computational Efficiency in Continu..." refers methods in this paper
...The primary approach ctsem uses for this is based on matrix exponentiation, as this is near perfect (up to accuracy of the exponential algorithm) for linear systems and can have higher accuracy for moderately non-linear systems (Hochbruck et al., 1998)....
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180 citations
"Computational Efficiency in Continu..." refers methods in this paper
...For improved uncertainty quantification, adaptive importance sampling (Oh & Berger, 1992) can be requested, which uses the maximum likelihood (or posterior mode when priors are used) and estimated asymptotic covariance matrix as an initial proposal distribution....
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152 citations
"Computational Efficiency in Continu..." refers methods in this paper
...This approach they favor is actually what is used in the original mixed effects implementation of ctsem (Driver et al., 2017), which used OpenMx to implement CT models using a RAM (McArdle, 2005) formulation of SEM....
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...…a Bayesian SEM style approach to the estimation of continuous time dynamic systems models, and claim dramatic computational improvements over the hierarchical Bayesian instantiation (Driver & Voelkle, 2018) of the ctsem (Continuous Time Structural Equation Modeling) software (Driver et al., 2017)....
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83 citations
"Computational Efficiency in Continu..." refers methods in this paper
...At present one alternative is available within ctsem, using a Taylor–Heun-approximation of the vector field and a modified Gauss–Legendre-scheme for the covariance (Mazzoni, 2008), but testing of this is very limited and it is unclear under which circumstances `good enough’ answers are obtained....
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...The default is for maximum likelihood estimation using a form of hybrid (discrete observations, continuous time) extended Kalman filter (Mazzoni, 2008), in which individuals system and measurement parameters may all vary as correlated random effects, fixed effects via covariates, or some…...
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