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Journal ArticleDOI

Computer calculation of equilibrium constants of species present in mixtures of metal ions and complexing agents.

01 Dec 1968-Talanta (Talanta)-Vol. 15, Iss: 12, pp 1397-1411
TL;DR: The program, which employs the non-linear least-squares method, may be used to calculate equilibrium constants for hydrolysed metal ions, protonated ligands, and simple, Protonated, Hydrolysed, polynuclear, and mixed complexes.
About: This article is published in Talanta.The article was published on 1968-12-01. It has received 297 citations till now. The article focuses on the topics: Equilibrium constant & Metal ions in aqueous solution.
Citations
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TL;DR: A new family of highly fluorescent indicators has been synthesized for biochemical studies of the physiological role of cytosolic free Ca2+ using an 8-coordinate tetracarboxylate chelating site with stilbene chromophores that offer up to 30-fold brighter fluorescence.

21,582 citations

Journal ArticleDOI
TL;DR: The intracellularly trappable fluorescent Ca2+ indicator quin-2 was used to measure free cytosolic Ca2+, [Ca2+]i, in the two highly dedifferentiated tumor cell lines, Ehrlich and Yoshida ascites carcinomas, and it was found that endogenous heavy metals are responsible for partially quenching quin2 fluorescence trapped inside the cells.

467 citations

Journal ArticleDOI
01 Jan 1974-Talanta
TL;DR: A new computer programme for the computation of formation constants of complex species in solution is presented, which can be applied to all kinds of potentiometric titration data, including multi-reactant and multi-electrode systems.

434 citations

References
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Journal ArticleDOI
01 Jul 1967-Talanta
TL;DR: A method is described for calculating equilibrium concentrations of all species in multi-metal-multi-ligand mixtures from the pH of the solution, the total concentration of each metal and each complexing agent, and the relevant equilibrium constants (pK(a) values and stability constants).

625 citations

Journal ArticleDOI
TL;DR: The main purpose of as mentioned in this paper is to apply the general theory of least squares adjustment to problems in physical chemistry, and apply it to the problem of least square adjustment in the setting of physical chemistry.
Abstract: The primary purpose of this paper is to apply the general theory of least squares adjustment to problems in physical chemistry.

181 citations