Journal Article•
Congenital diarrhea with chloride loss and metabolic alkalosis. Congenital alkalosis with diarrhea
About: This article is published in Archivos Argentinos De Pediatria.The article was published on 1971-06-01 and is currently open access. It has received 1 citations till now. The article focuses on the topics: Alkalosis & Metabolic alkalosis.
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TL;DR: The only ions known to be involved in specific malabsorption states are Zn+ (Rahanzadeh and Danzig 1974), Cu2+ (Danks et al. 1972) and C1-. Malabsorption of C1- is known as congenital chloride diarrhea (CCD) as discussed by the authors.
Abstract: Specific disturbances of intestinal electrolyte transport are very rare. More often, absorption of water and electrolytes is impaired along with the absorption of amino acids, fatty acids, sugars, and vitamins in states of generalized malabsorption, as in familial enteropathy with hypoplastic villous atrophy (Davidson et al. 1978). Chronic inflammation of the gut, e.g., colitis ulcerosa, may also be accompanied by malabsorption of electrolytes and water (Dutchie et al. 1964; Edmonds and Pilcher 1973; Harris and Shield 1970; Rask-Madsen 1973). In addition, reversible electrolyte malabsorption, “secondary chloride-losing diarrhea” may result from intestinal surgery even in normal children (Aaronson 1971). Other factors causing secondary impairment may be increased levels of gastrointestinal hormones, VIP, GIP, gastrin, secretin (Walsh 1981), and calcitonin (Gray et al. 1973) produced by tumors, diseases with increased intestinal bile acid concentrations (Binder 1980), and infections with intestinal toxin production such as cholera and E. coli gastroenteritis (Fishman 1980; Sack 1975). The only ions known to be involved in specific malabsorption states are Zn+ (Rahanzadeh and Danzig 1974), Cu2+ (Danks et al. 1972) and C1-. Malabsorption of C1- is known as congenital chloride diarrhea (CCD). This disease was at first namend “congenital alkalosis with diarrhea” (Darrow 1945; Gamble et al. 1945). Later, it was called “congenital chloridorrhea” and “familial chloride diarrhea.” Today the name “congenital chloride diarrhea” appears to be generally accepted.
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