Conjugated polymer/porphyrin complexes for efficient energy transfer and improving light-activated antibacterial activity
24 Aug 2009-Journal of the American Chemical Society (American Chemical Society)-Vol. 131, Iss: 36, pp 13117-13124
TL;DR: The PTP/TPPN technique provides a promising application in photodynamic inactivation of bacteria on the basis of enhanced energy transfer offered by light-harvesting conjugated polymers.
Abstract: With the increasing antibiotic resistance of microorganisms, there is a growing interest in the design and development of new materials that are effective in killing bacteria to replace conventional antibiotics. Herein, a new anionic water-soluble polythiophene (PTP) and a cationic porphyrin (TPPN) are synthesized and characterized. They can form a complex through electrostatic interactions, and efficient energy transfer from PTP to TPPN occurs upon irradiation under white light (400-800 nm). The energy of TPPN transfers to triplet by intersystem crossing, followed by sensitization of oxygen molecule to enhance the efficiency of singlet oxygen generation related to TPPN itself. The positive charges of PTP/TPPN complex promote its adsorption to the negatively charged bacteria membranes of gram-negative Escherichia coli and gram-positive Bacillus subtilis through electrostatic interactions, and the singlet oxygen effectively kills the bacteria. The photosensitized inactivation of bacteria for the PTP/TPPN complex is efficient, and about 70% reduction of bacterial viability is observed after only 5 min of irradiation with white light at a fluence rate of 90 mW x cm(-2) (27 J x cm(-2)). The technique provides a promising application in photodynamic inactivation of bacteria on the basis of enhanced energy transfer offered by light-harvesting conjugated polymers.
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TL;DR: The state of the art in the field of antimicrobial polymeric systems during the last decade is described in this paper, where a classification of the different materials is carried out dividing basically those synthetic polymers that exhibit antimicrobial activity by themselves; those whose biocidal activity is conferred through their chemical modification; those that incorporate antimicrobial organic compounds with either low or high molecular weight; and those that involve the addition of active inorganic systems.
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TL;DR: This tutorial review provides a recent development of the preparation methods, properties, and functionalization strategies of CPNs, especially discussing their biological applications in targeted imaging, drug/gene delivery and biomedicine.
Abstract: In the past few years, conjugated polymer nanoparticles (CPNs) have been successfully prepared and applied in the biological field because of their unique opto-electronic properties. The rapid development of CPNs is mainly attributed to their simple synthesis procedures and easy separation steps. The advantages of CPNs include high brightness, excellent photostability, low cytotoxicity, high quantum yield and versatile surface modification. The functionalization of CPNs with specific recognition elements imparts them good ability for targeted recognition and imaging in vitro and in vivo. CPNs can be applied to deliver drug and gene, and simultaneously to real-time monitor the release process due to their self-luminous characteristics. Moreover, CPNs can sensitize oxygen molecules to generate reactive oxygen species (ROS) which can kill adjacent bacteria and tumor cells. In this tutorial review, we provide a recent development of the preparation methods, properties, and functionalization strategies of CPNs, especially discussing their biological applications in targeted imaging, drug/gene delivery and biomedicine. The challenges and outlooks in this field will also be discussed.
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TL;DR: Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China
Abstract: Excitation Energy Transfer Hui-Qing Peng,† Li-Ya Niu,†,‡ Yu-Zhe Chen,† Li-Zhu Wu,† Chen-Ho Tung,*,†,§ and Qing-Zheng Yang*,†,‡ †Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China ‡Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, People’s Republic of China Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Shandong Normal University, Jinan 250014, People’s Republic of China
351 citations
TL;DR: Organic Photocatalysts for the Oxidation of Pollutants and Model Compounds M. Miranda-UPV-CSIC, Avda.
Abstract: Financial support from the Spanish Government (CTQ2009-
13699, CTQ2009-13459-C05-03/PPQ, RIRRAF RETICS), and
the Generalitat Valenciana (Prometeo Program) is gratefully
acknowledged. Dedicated to Prof. Avelino Corma on the occasion of his 60th birthday.
345 citations
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