Journal ArticleDOI
Conjugated Polymers with Aggregation-Induced Emission Characteristics for Fluorescence Imaging and Photodynamic Therapy.
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TLDR
In this article, the authors highlight recent progress in aggregation-induced emission conjugated polymers and their applications in anticancer and antibacterial areas based on fluorescence imaging (FL) and photodynamic therapy (PDT).Abstract:
Accurate diagnosis and treatment have been extensively developed in the field of biomedicine, which puts forward higher requirements for the development of biomedical materials with high efficiency and selectivity. Among them, aggregation-induced emission (AIE) conjugated polymers have stood out in recent years owing to their unique properties, such as intense solid emission, high light-harvesting ability, efficient energy transfer, and high 1 O 2 generation ability, which empower them effectively biomedical functions in fluorescence imaging (FL), photodynamic therapy (PDT), FL guided PDT, two-photon excited photodynamic therapy (2PE-PDT), etc . In this review, we highlight recent progress in AIE conjugated polymers and their applications in anticancer and antibacterial areas based on FL and PDT, and summarize the mechanism of color-tuned fluorescent emission and efficient 1 O 2 generation ability compared with small molecular photosensitizer. Last but not least, the challenges and perspectives for the future development of AIE conjugated polymers are discussed.read more
Citations
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Journal ArticleDOI
Recent Advances in AIEgen-Based Photodynamic Therapy and Immunotherapy.
TL;DR: Li et al. as mentioned in this paper reviewed the recent advances in the AIEgen-based enhanced photodynamic immunotherapy, with a special focus on the aggregation-induced emission (AIE) photosensitizers.
Journal ArticleDOI
Multifunctional nanotheranostics for near infrared optical imaging-guided treatment of brain tumors.
TL;DR: In this paper , the authors provide a systematic summary of the state-of-the-art NIR contrast agents (CAs) for brain tumors single-modal imaging (e.g., FLI and PAI), dual-and triple-mode imaging, and discuss the opportunities and challenges of the CAs and nanotheranostics for future clinic translation.
Journal ArticleDOI
AIE-Active Photosensitizers: Manipulation of Reactive Oxygen Species Generation and Applications in Photodynamic Therapy
Hao Yu,Binjie Chen,Huiming Huang,Zhentao He,Jiangman Sun,Guan Wang,Xinggui Gu,Ben Zhong Tang +7 more
TL;DR: AIE-active photosensitizers have been developed with biocompatibility, effective reactive oxygen species (ROS) generation, and superior absorption, bringing about great interest for applications in oncotherapy as discussed by the authors .
Journal ArticleDOI
Vision Defense: Efficient Antibacterial AIEgens Induced Early Immune Response for Bacterial Endophthalmitis
TL;DR: Wang et al. as mentioned in this paper used a cationic aggregation-induced emission luminogen named with triphenylamine thiophen pyridinium (TTPy) for photodynamic treatment of bacterial endophthalmitis.
Journal ArticleDOI
Vision redemption: Self-reporting AIEgens for combined treatment of bacterial keratitis.
Chen Peng,Chen Peng,Wenjie Sun,Chengcheng Zhou,Sujing Qiang,Meijuan Jiang,Jacky Wing Yip Lam,Zheng Zhao,Ryan T. K. Kwok,Wenting Cai,Ben Zhong Tang,Ben Zhong Tang +11 more
TL;DR: In this article, a cationic diphenyl luminogen with aggregation-induced emission called IQ-Cm containing isoquinolinium and coumarin units for theranostic study of BK is reported.
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Photosensitizers with Aggregation-Induced Emission: Materials and Biomedical Applications
Fang Hu,Shidang Xu,Bin Liu +2 more
TL;DR: In this paper, the design principles of aggregation-induced emission (AIE) PSs and their biomedical applications are discussed in detail, starting with a summary of traditional PSs, followed by a comparison between traditional and AIE PSs to highlight various design strategies and unique features of the latter.
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