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Consensus guidelines for the management and treatment of neuroendocrine tumors.

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TLDR
A set of consensus tables intended to complement the North American Neuroendocrine Tumor Society guidelines and serve as a quick, accessible reference for the practicing physician are presented.
Abstract
Neuroendocrine tumors are a heterogeneous group of tumors originating in various anatomic locations. The management of this disease poses a significant challenge because of the heterogeneous clinical presentations and varying degrees of aggressiveness. The recent completion of several phase 3 trials, including those evaluating octreotide, sunitinib, and everolimus, demonstrate that rigorous evaluation of novel agents in this disease is possible and can lead to practice-changing outcomes. Nevertheless, there are many aspects to the treatment of neuroendocrine tumors that remain unclear and controversial. The North American Neuroendocrine Tumor Society published a set of consensus guidelines in 2010, which provided an overview for the treatment of patients with these malignancies. Here, we present a set of consensus tables intended to complement these guidelines and serve as a quick, accessible reference for the practicing physician.

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Journal ArticleDOI

Gastroenteropancreatic high-grade neuroendocrine carcinoma.

TL;DR: Platinum‐based chemotherapy may not be the optimal treatment for patients who have GEP‐NEC with a moderately high proliferation rate, and patients with such tumors or with well differentiated morphology had better survival than patients who had tumors with poorly differentiated morphology or a higher Ki‐67 index.
Journal ArticleDOI

Consensus on biomarkers for neuroendocrine tumour disease

TL;DR: A multinational consensus meeting of multidisciplinary experts in neuroendocrine tumours assessed the use of current biomarkers and defined the perquisites for novel biomarkers via the Delphi method and concluded that circulating multianalyte biomarkers provide the highest sensitivity and specificity necessary for minimum disease detection.
References
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Journal ArticleDOI

Placebo-Controlled, Double-Blind, Prospective, Randomized Study on the Effect of Octreotide LAR in the Control of Tumor Growth in Patients With Metastatic Neuroendocrine Midgut Tumors: A Report From the PROMID Study Group

TL;DR: Octreotide LAR demonstrates substantial tumor control and shows a more favorable antiproliferative response than placebo as two-thirds of patients treated with octreotide ARL achieved stable disease at 6 mos, and patients treatment-naïve patients with histologically confirmed locally inoperable or metastasized well-differentiated NETs had a 66% risk reduction of tumor progression.
Journal ArticleDOI

Treatment With the Radiolabeled Somatostatin Analog [177Lu-DOTA0,Tyr3]Octreotate: Toxicity, Efficacy, and Survival

TL;DR: Treatment with peptide receptor radionuclide therapy with the radiolabeled somatostatin analog [(177)Lu-DOTA(0),Tyr(3)]octreotate has few adverse effects and compares favorably to the limited number of alternative treatment modalities.
Journal ArticleDOI

The pathologic classification of neuroendocrine tumors: a review of nomenclature, grading, and staging systems.

TL;DR: Issues in the pathologic assessment of NETs that are common among primaries of different sites are examined and the distinction of well-differentiated from poorly differentiated NETs and the significance of proliferative rate in prognostic assessment are examined.
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