Journal ArticleDOI
Contribution of astrocytes to neuropathology of neurodegenerative diseases.
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TLDR
A review of the contribution of microglia to neurodegenerative diseases with particular emphasis on Alzheimer's disease, Parkinson disease, amyotrophic lateral sclerosis and frontotemporal dementia is presented in this paper.About:
This article is published in Brain Research.The article was published on 2021-01-28. It has received 43 citations till now. The article focuses on the topics: Neuroprotection & Neuroinflammation.read more
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A1/A2 astrocytes in central nervous system injuries and diseases: Angels or devils?
Yanying Fan,Jing Huo +1 more
TL;DR: Astrocytes play a pivotal role in maintaining the central nervous system (CNS) homeostasis and function, and reactive astrocytes are triggered in response to CNS injuries and diseases as mentioned in this paper.
Journal ArticleDOI
Glial cells in Alzheimer’s disease: From neuropathological changes to therapeutic implications
Md. Sahab Uddin,Lee Wei Lim +1 more
TL;DR: In this paper , the implications of microglia and astrocytes in AD pathogenesis are discussed, and the mechanisms of therapeutic agents that exhibit anti-inflammatory effects against AD are discussed.
Journal ArticleDOI
First-in-Humans Evaluation of 18F-SMBT-1, a Novel 18F-Labeled Monoamine Oxidase-B PET Tracer for Imaging Reactive Astrogliosis
Victor L Vilemagne,Ryuichi Harada,Vincent Dorcet,Shozo Furumoto,Rachel S. Mulligan,Yukitsuka Kudo,Samantha C. Burnham,Natasha Krishnadas,Svetlana Bozinovski,Kun Huang,Brian J. Lopresti,Kazuhiko Yanai,Christopher C. Rowe,Nobuyuki Okamura +13 more
TL;DR: 18F-SMBT-1 showed robust entry into the brain and reversible binding kinetics, with high tracer retention in basal ganglia, intermediate retention in cortical regions, and the lowest retention in cerebellum and white matter, which tightly follows the known regional brain distribution of MAO-B.
Journal ArticleDOI
Dysregulation of Astrocyte–Neuronal Communication in Alzheimer’s Disease
TL;DR: In this article, the role of astrocytes at synapses in Alzheimer's disease has been investigated, and it was shown that their role in regulating synaptic plasticity and neuronal excitability via the release of neuroactive substances named gliotransmitters.
Journal ArticleDOI
Assessing Reactive Astrogliosis with 18F-SMBT-1 Across the Alzheimer Disease Spectrum
Victor L Vilemagne,Ryuichi Harada,Vincent Dorcet,Shozo Furumoto,Rachel S. Mulligan,Yukitsuka Kudo,Samantha C. Burnham,Natasha Krishnadas,Pierrick Bourgeat,Ying Xia,Simon M. Laws,Svetlana Bozinovski,Kun Huang,Milos D. Ikonomovic,Jurgen Fripp,Kazuhiko Yanai,Nobuyuki Okamura,Christopher C. Rowe +17 more
TL;DR: It is suggested that increased 18F-SMBT-1 binding is detectable at the preclinical stages of Aβ accumulation, providing strong support for its use as a surrogate marker of astrogliosis in the AD continuum.
References
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Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TL;DR: The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.
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Pattern Recognition Receptors and Inflammation
Osamu Takeuchi,Shizuo Akira +1 more
TL;DR: The role of PRRs, their signaling pathways, and how they control inflammatory responses are discussed.
Journal ArticleDOI
Alzheimer's Disease: Genes, Proteins, and Therapy
TL;DR: Evidence that the presenilin proteins, mutations in which cause the most aggressive form of inherited AD, lead to altered intramembranous cleavage of the beta-amyloid precursor protein by the protease called gamma-secretase has spurred progress toward novel therapeutics and provided discrete biochemical targets for drug screening and development.
Journal ArticleDOI
Neurotoxic reactive astrocytes are induced by activated microglia
Shane A. Liddelow,Kevin A. Guttenplan,Laura E. Clarke,Frederick C. Bennett,Christopher J. Bohlen,Lucas Schirmer,Mariko L. Bennett,Alexandra E. Münch,Won-Suk Chung,Todd C. Peterson,Daniel K. Wilton,Arnaud Frouin,Brooke A. Napier,Nikhil Panicker,Manoj Kumar,Marion S. Buckwalter,David H. Rowitch,Valina L. Dawson,Ted M. Dawson,Beth Stevens,Ben A. Barres +20 more
TL;DR: It is shown that activated microglia induce A1 astrocytes by secreting Il-1α, TNF and C1q, and that these cytokines together are necessary and sufficient to induce A2 astroCytes, which are abundant in various human neurodegenerative diseases.
Journal ArticleDOI
Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS
Mariely DeJesus-Hernandez,Ian R. A. Mackenzie,Bradley F. Boeve,Adam L. Boxer,Matt Baker,Nicola J. Rutherford,Alexandra M. Nicholson,Ni Cole A. Finch,Heather C. Flynn,Jennifer Adamson,Naomi Kouri,Aleksandra Wojtas,Pheth Sengdy,Ging-Yuek Robin Hsiung,Anna Karydas,William W. Seeley,Keith A. Josephs,Giovanni Coppola,Daniel H. Geschwind,Zbigniew K. Wszolek,Howard Feldman,Howard Feldman,David S. Knopman,Ronald C. Petersen,Bruce L. Miller,Dennis W. Dickson,Kevin B. Boylan,Neill R. Graff-Radford,Rosa Rademakers +28 more
TL;DR: It is found that repeat expansion in C9ORF72 is a major cause of both FTD and ALS, suggesting multiple disease mechanisms.