Contribution of platelets to tumour metastasis.
Citations
5,396 citations
1,930 citations
Cites background from "Contribution of platelets to tumour..."
...…when studies revealed that experimental induction of thrombocytopenia can exert an anti-metastatic effect (Gasic et al., 1968), while a high platelet count has for years been known to be associated with a poor clinical prognosis across diverse types of carcinomas (Gay and Felding-Habermann, 2011)....
[...]
...674 Cell 168, February 9, 2017 disseminated intravascular coagulation, and even large pulmonary emboli (Gay and Felding-Habermann, 2011)....
[...]
...Platelets contain a plethora of bioactive molecules that can potentially impact cancer progression and work in more recent years has revealed a number of mechanisms by which platelets can alter the fate of carcinoma cells in transit (Franco et al., 2015; Gay and Felding-Habermann, 2011)....
[...]
...…the normal homeostatic controls on coagulation, which can result in certain clotting symptoms that are seen in patients with cancer, specifically microthrombi, 674 Cell 168, February 9, 2017 disseminated intravascular coagulation, and even large pulmonary emboli (Gay and Felding-Habermann, 2011)....
[...]
..., 1968), while a high platelet count has for years been known to be associated with a poor clinical prognosis across diverse types of carcinomas (Gay and Felding-Habermann, 2011)....
[...]
1,367 citations
Cites background from "Contribution of platelets to tumour..."
...…lysis (Nieswandt et al., 1999; Palumbo et al., 2005), limits their exposure to shear stress, and promotes their adhesion to the endothelium (Erpenbeck and Schön, 2010; Gay and Felding-Habermann, 2011; Im et al., 2004; Jain et al., 2007; Karpatkin et al., 1988; Sierko andWojtukiewicz, 2007)....
[...]
..., 2005), limits their exposure to shear stress, and promotes their adhesion to the endothelium (Erpenbeck and Schön, 2010; Gay and Felding-Habermann, 2011; Im et al., 2004; Jain et al., 2007; Karpatkin et al., 1988; Sierko andWojtukiewicz, 2007)....
[...]
1,134 citations
1,073 citations
References
9,874 citations
Additional excerpts
...Angiogenesis was originally hypothesized by Judah Folkma...
[...]
3,863 citations
3,810 citations
3,332 citations
"Contribution of platelets to tumour..." refers background in this paper
...Cells within the bloodstream that contribute to metastasis are endothelial cells, platelets, lymphocytes, macrophages, mast cells, fibroblasts and bone marrow-derived progenitor cell...
[...]
2,894 citations