Contributions of Antibiotic Penetration, Oxygen Limitation, and Low Metabolic Activity to Tolerance of Pseudomonas aeruginosa Biofilms to Ciprofloxacin and Tobramycin
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...The creation of starved, stationary phase dormant zones in biofilms seems to be a significant factor in the resistance of biofilm populations to antimicrobial...
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2,637 citations
Additional excerpts
...of biofilms to aminoglycosides and ciprofloxacin (69)....
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2,420 citations
Cites background from "Contributions of Antibiotic Penetra..."
...…the efficacy of quinolones in stationary phase can be enhanced by adding oxygen to a stationary-phase culture (Morrissey and Smith, 1994), and recent evidence suggests that metabolic activity and oxygen tension are important indicators of quinolone activity against biofilms (Walters et al., 2003)....
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...Also, the efficacy of quinolones in stationary phase can be enhanced by adding oxygen to a stationary-phase culture (Morrissey and Smith, 1994), and recent evidence suggests that metabolic activity and oxygen tension are important indicators of quinolone activity against biofilms (Walters et al., 2003)....
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1,953 citations
Cites methods from "Contributions of Antibiotic Penetra..."
...Another strategy for visualizing patterns of protein synthetic activity is to use an inducible GFP construc...
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1,730 citations
References
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"Contributions of Antibiotic Penetra..." refers background in this paper
...One explanation for the chronic nature of some infections involving the opportunistic pathogen Pseudomonas aeruginosa is that this organism is adept at forming biofilms in which the bacteria are protected from host defenses and from killing by antibiotics (6)....
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4,116 citations
"Contributions of Antibiotic Penetra..." refers background in this paper
...The protection of bacteria growing in biofilms from antibiotics probably depends on multiple factors (3, 19, 27, 28)....
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3,295 citations
"Contributions of Antibiotic Penetra..." refers background in this paper
...aeruginosa by triparental mating with the conjugation helper plasmid pRK2013 (11)....
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3,093 citations