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Journal ArticleDOI

Coordination properties of the bioligands creatinine and creatine in various reaction media

Mariana Mitewa1
01 Mar 1995-Coordination Chemistry Reviews (Elsevier)-Vol. 140, pp 1-25
TL;DR: In this article, the ability of the important bioligands creatinine and creatine to form various types of complexes with different metal ions is summarized and the crucial role of the nature of the reaction medium in complex formation with these ligands is emphasized.
About: This article is published in Coordination Chemistry Reviews.The article was published on 1995-03-01. It has received 34 citations till now.
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Journal ArticleDOI
Mariana Mitewa1
TL;DR: In this paper, the ability of the important bioligands creatinine and creatine to form various types of complexes with different metal ions is summarized and the crucial role of the nature of the reaction medium in complex formation with these ligands is emphasized.
Abstract: Data on the ability of the important bioligands creatinine and creatine to form various types of complexes with different metal ions are summarized. The crucial role of the nature of the reaction medium in complex formation with these ligands is emphasized. The conditions for obtaining paramagnetic oligomeric platinum complexes of the “platinum blue” type (resulting from multistep redox and coordination processes) are presented.

4 citations

01 Jan 2014
TL;DR: In this article, a potentiometric titration technique has been used to determine stability constants for the various complexes of Zn, Co, Cd, and Mn(II) with creatinine and two amino acids.
Abstract: In this study, a potentiometric titration technique has been used to determine stability constants for the various complexes of Zn(II), Co(II), Cd(II) and Mn(II) with creatinine and two amino acids. Stability constants of ternary systems have been evaluated by the method suggested by Irving-Rossotti at 25°C and 0.11M ionic strength (kept constant with NaC104) in aqueous solution. In addition, the conditional con­ stants were calculated as a function of pH. The maximum values of the conditional formation constants were found to be in accordance with the mixed-ligand complex formation constants in a given pH region. In addition, the mole fractions of different species from mixed complexes were calculated by means of formation constants. The values of stability constants of mixed-ligand complexes at 25°C were calculated as follows: logK=3.20 for Zn(II)-L-cysteine-creatinine,logK1=4.24 and logK2=3.58 for Co(II)-L-cysteinecreatinine2, logK=3.22 for Cd(II) L-cysteine creatinine, logK=3.65 for Mn(II) L-cysteine creatinine and logK=5.34 for Co(II)-BDHL-cysteine-creatinine, logK=5.30 for Cd(II)-BDHL-cysteine-creatinine, logK,=5.35 and logK =3.93 for Zn(II) BDHL-cysteine creatinine^, logK,=5.40 and logK =3.49 for Mn(II) BDHL-cysteine creatinine,,

4 citations


Cites background from "Coordination properties of the biol..."

  • ...chelat s have now been m a ured at constant The determination of the structure of metal temperature and ionic strength (2)....

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  • ...Because of the biological reported metal-stability constants have been importance of these ligands, several of the redetermined and those of several new metal report d metal-stability constants have bee chelates have now been measured at constant r det rmined and those of several new metal temperature and ionic strength (2)....

    [...]

Journal ArticleDOI
TL;DR: Pd(creat)2Cl2·2H2O crystallizes in space group P&1macr; with a= 7.257(2), b= 8.159 (2), c= 14.640(2) A, f = 73.0(1), u = 72.22 (2)°, Z=2, and represents a new allotropic form of this compound as discussed by the authors.
Abstract: Pd(creat)2Cl2·2H2O crystallizes in space group P&1macr; with a= 7.257(2), b= 8.159(2), c= 14.640(2) A, f =73.97(2), g =77.0(1), u =72.22(2)°, Z=2, and represents a new allotropic form of this compound. Pd atoms have planar fourfold coordination of N and Cl atoms in trans configuration. Creatinine moieties are coordinated to the Pd atoms via endocyclic N atoms and their essential planarity causes significant delocalization of electron density. The structure is stabilized by a system of weak hydrogen bonds involving interstitial water molecules and creatinine amino-groups.

4 citations

Journal ArticleDOI
TL;DR: In this article, the formation of an octahedral low-spin PdL was proved exhibiting an anisotropic 2-component EPR spectrum (g1=2.007 and gu=1.998) and effective magnetic moment μeff = 1.7 BM.
Abstract: Formation of transient Pd(III) species was established in the course of PdCL42−-bilirubin (BR) reaction in basic-water medium. Using the EPR method the formation of an octahedral low-spin PdL.2H2O complex was proved exhibiting an anisotropic 2-component EPR spectrum (g1=2.007 and gu=1.998) and effective magnetic moment μeff = 1.7 BM.

4 citations

References
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Journal ArticleDOI
TL;DR: Preliminary mechanism studies indicated that the 3,4-dihydroxyphenylguanidines act at least partially by a direct alpha-adrenergic mechanism.
Abstract: A series of aromatic guanidines and several 1-phenylbiguanides was prepared and tested for cardiovascular (CV) effects in anesthetized dogs measuring heart rate, blood pressure, carotid artery blood flow, and myocardial force changes. The predominant CV effect at minimally effective dose was vasoconstriction unassociated with cardiac stimulation. The structure-activity relationships of the compounds were discussed comparing their structural similarities to the beta-phenylethylamines. The most potent members of the series were phenylguanidines substituted in the 3 and 4 positions on the aromatic nucleus with hydroxy or chloro groups. Preliminary mechanism studies indicated that the 3,4-dihydroxyphenylguanidines act at least partially by a direct alpha-adrenergic mechanism

42 citations

Journal ArticleDOI
TL;DR: In this paper, the crystal and molecular structure of creatinininium tetrachlorocuprate (II) was described and the structure was solved by X-ray diffraction studies and was refined by least-squares methods to R = 0.041 for 1344 reflections.

40 citations

Journal ArticleDOI
TL;DR: Pt(II) and Pd(II)-complexes with creatinine, C3H2N2(O)(CH3)NH2, were synthesized in this paper and a model for coordination of the ligands to the central atoms was confirmed by X-ray structural investigation.

26 citations