Coordination properties of the bioligands creatinine and creatine in various reaction media
TL;DR: In this article, the ability of the important bioligands creatinine and creatine to form various types of complexes with different metal ions is summarized and the crucial role of the nature of the reaction medium in complex formation with these ligands is emphasized.
About: This article is published in Coordination Chemistry Reviews.The article was published on 1995-03-01. It has received 34 citations till now.
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TL;DR: Creatinine is an amino acid derived from creatine catabolism at different steps of the body's organs, and its detection is significant because levels out of normal values are linked to some diseases like kidney failure.
Abstract: Creatinine is an amino acid derived from creatine catabolism at different steps of the body's organs, and its detection is significant because levels out of normal values are linked to some diseases like kidney failure. Normal concentration levels of creatinine in blood are from 45 to 110 μM, while in urine, typical concentrations range between 3.3 to 27 mM, and in saliva from 8.8 and 26.5 μM. Nowadays, the creatinine detection is carried through different spectroscopic-colorimetric methods; however, the resulting values present errors due to high interferences, delayed analysis, and poor stability. Electrochemical sensors have been an alternative to creatinine detection, and the electrochemical methods have been adapted to detect in enzymatic and non-enzymatic sensors, the latter being more relevant in recent years. Nanomaterials have made creatinine sensors more stable, sensitive, and selective. This review presents recent advances in creatinine electrochemical sensors for advances in point-of-care (POC) sensing devices, comprising both a materials point of view and prototypes for advanced sensing. The effect of the metal, particle size, shape and other morphological and electronic characteristics of nanomaterials are discussed in terms of their impact on the effective detection of creatinine. In addition, the application of nanomaterials in POC devices is revised pointing to practical applications and looking for more straightforward and less expensive devices to manufacture.
3 citations
TL;DR: In this paper, five coordination modes have been established by X-ray crystallography: bidentate bridging through N(l)(r ing) and deprotonated exocyclic NH site 191, Bidentate binding via N ( l ) (ring) and the exocycyclic 0 ( C = 0 ) (11); monodentate binding through the N (l ) ( ring) site /11/; monodente binding through N (c = 0 ǫ ) /12/; and monodenta binding through
Abstract: Creatinine, being a natural metabolite of creatin, is a very important bioligand. Its importance in clinical chemistry is well recognized; its level in serum and urine is indicative of the renal function / l , 2/. The complexation ability of creatinine, due to the presence of several donor groups in its main tautomeric form, is well recognised and studies on the metal ion interactions with creatinine may be helpful in deciphering creatinine metabolic pathways /3, 4, 5, 6, 7/. The study of binary and ternary complexes of this ligand should be of interest due to the fact that creatinine metabolism might be connected with its complcxation to different metal ions 191. Five co-ordination modes have been established by X-ray crystallography:bidentate bridging through N(l)(r ing) and deprotonated exocyclic NH site 191, bidentate binding via N ( l ) (ring) and the exocyclic 0 ( C = 0 ) (11); monodentate binding through the N ( l ) (ring) site /11/; monodentate binding through the exocyclic 0 ( C = 0 ) /12/; and monodentate fashion through the deprotonated exocyclic NH group /10/.
2 citations
TL;DR: In this article, the authors presented a decomposition sequence of creatinine complexes of nickel(II) with various anions and showed that the loss of coordinated water is reversible in the case of [Ni(creat)2(H2O)2]Cl2.
2 citations
TL;DR: In this article, the structural, spectroscopic and theoretical study of cyclocreatine (1-carboxymethyl-2-iminoimidazolidine, CyCre) has been performed prompted by the biological relevance of the molecule and its potential role as a ligand in biometalic compounds.
2 citations
TL;DR: Sulfonated derivatives of cobalt phthalocyanine strongly fix the creatinine (2-amino-1-methyl-1 H -imidazol-4-ol) thus forming ordered dimeric structures as mentioned in this paper.
2 citations
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62 citations
46 citations
TL;DR: Preliminary mechanism studies indicated that the 3,4-dihydroxyphenylguanidines act at least partially by a direct alpha-adrenergic mechanism.
Abstract: A series of aromatic guanidines and several 1-phenylbiguanides was prepared and tested for cardiovascular (CV) effects in anesthetized dogs measuring heart rate, blood pressure, carotid artery blood flow, and myocardial force changes. The predominant CV effect at minimally effective dose was vasoconstriction unassociated with cardiac stimulation. The structure-activity relationships of the compounds were discussed comparing their structural similarities to the beta-phenylethylamines. The most potent members of the series were phenylguanidines substituted in the 3 and 4 positions on the aromatic nucleus with hydroxy or chloro groups. Preliminary mechanism studies indicated that the 3,4-dihydroxyphenylguanidines act at least partially by a direct alpha-adrenergic mechanism
42 citations
TL;DR: In this paper, the crystal and molecular structure of creatinininium tetrachlorocuprate (II) was described and the structure was solved by X-ray diffraction studies and was refined by least-squares methods to R = 0.041 for 1344 reflections.
40 citations
TL;DR: Pt(II) and Pd(II)-complexes with creatinine, C3H2N2(O)(CH3)NH2, were synthesized in this paper and a model for coordination of the ligands to the central atoms was confirmed by X-ray structural investigation.
26 citations