Copper Toxicity Links to Pathogenesis of Alzheimer's Disease and Therapeutics Approaches.
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"Copper Toxicity Links to Pathogenes..." refers background in this paper
...Though 20–40% of healthy cases have amyloid plaques, as illustrated by some studies [333]....
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2,693 citations
"Copper Toxicity Links to Pathogenes..." refers background in this paper
...The soluble oligomers obtained from the culturing of cells possess high chemical resistance and protect against its conversion into monomers via several degrading factors and maintain the presence of covalent cross-links in them [134,135]....
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2,449 citations
"Copper Toxicity Links to Pathogenes..." refers background in this paper
...One of the most common neuropathological hallmarks of AD is the misfolding and aggregation of amyloid plaques-extracellular insoluble deposits of the β-amyloid peptides [21], and the intracellular formed NFTs (neurofibrillary tangles) [22], leading to the loss of communication between nerve cells, causes brain damage and shrinkage [23]....
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"Copper Toxicity Links to Pathogenes..." refers background in this paper
...Furthermore, in parallel, antibody-based treatment for Aβ aggregation is now developing and providing safe results as well [337]....
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