Corilagin prevents SARS-CoV-2 infection by targeting RBD-ACE2 binding.
Li Jun Yang,Rui Hong Chen,Sami Hamdoun,Paolo Coghi,Jerome P.L. Ng,David Wei Zhang,Xiaoling Guo,Chenglai Xia,Betty Yuen Kwan Law,Vincent Kam Wai Wong +9 more
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Wang et al. as mentioned in this paper characterized an active compound, corilagin derived from Phyllanthus urinaria as potential SARS-CoV-2 entry inhibitors for its possible preventive application in daily anti-virus hygienic products.About:
This article is published in Phytomedicine.The article was published on 2021-05-05 and is currently open access. It has received 28 citations till now. The article focuses on the topics: Corilagin.read more
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Identification of natural compounds as SARS-CoV-2 entry inhibitors by molecular docking-based virtual screening with bio-layer interferometry.
Dingqi Zhang,Sami Hamdoun,Ruihong Chen,Li Jun Yang,Chi Kio Ip,Yuan-Qing Qu,Run-Feng Li,Haiming Jiang,Zifeng Yang,Sookja Kim Chung,Liang Liu,Vincent Kam Wai Wong +11 more
TL;DR: In this paper, the identification of natural compounds as potential SARS-CoV-2 entry inhibitors using the molecular docking-based virtual screening coupled with bilayer interferometry (BLI) was reported.
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Bioactive natural products in COVID-19 therapy
TL;DR: This paper reviewed published studies relating closely to bioactive natural products used in COVID-19 therapy in vitro to provide some essential guidance for anti-SARS-CoV-2 drug research and development.
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Significance of the RBD mutations in the SARS-CoV-2 omicron: from spike opening to antibody escape and cell attachment.
TL;DR: The computationally investigated the role of the omicron RBD mutations on its structure and interactions with the surrounding domains in the spike trimer as well as with ACE2, suggesting that the mutations facilitate a more efficient RBD "down" to "up" conformation.
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SARS-CoV-2 neutralizing activity of polyphenols in a special green tea extract preparation
TL;DR: In this paper , the authors investigated whether a sorbitol/lecithin-based throat spray containing concentrated green tea extract (sGTE) interacts with SARS-CoV-2 viral particles and additionally is capable to block the virus replication.
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Molecular Interactions of Tannic Acid with Proteins Associated with SARS-CoV-2 Infectivity
Mohamed Haddad,Roger Gaudreault,G. Sasseville,Phuong T. Nguyen,Hannah Wiebe,Theo G. M. van de Ven,Steve Bourgault,Normand Mousseau,Charles Ramassamy +8 more
TL;DR: A combination of experimental methods confirms the potential role of TA in the prevention of SARS-CoV-2 infectivity through the inhibition of extracellular RBD/ACE2 interactions and TMPRSS2 and 3CLpro activity and suggests that naturally occurring TA is a promising candidate to prevent and inhibit the infectivity of Sars-Cov-2.
References
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Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor.
Jun Lan,Jiwan Ge,Jinfang Yu,Sisi Shan,Huan Zhou,Shilong Fan,Qi Zhang,Xuanling Shi,Qisheng Wang,Linqi Zhang,Xinquan Wang +10 more
TL;DR: High-resolution crystal structures of the receptor-binding domain of the spike protein of SARS-CoV-2 and SARS -CoV in complex with ACE2 provide insights into the binding mode of these coronaviruses and highlight essential ACE2-interacting residues.
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Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2.
TL;DR: Cryo–electron microscopy structures of full-length human ACE2 in the presence of the neutral amino acid transporter B0AT1 with or without the receptor binding domain (RBD) of the surface spike glycoprotein of SARS-CoV-2 are presented, providing important insights into the molecular basis for coronavirus recognition and infection.
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Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19.
TL;DR: Recent research advance in the structure, function and development of antivirus drugs targeting the spike (S) protein of SARS-CoV-2 is highlighted.
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Spike mutation D614G alters SARS-CoV-2 fitness.
Jessica A. Plante,Yang Liu,Jianying Liu,Hongjie Xia,Bryan A. Johnson,Kumari G. Lokugamage,Xianwen Zhang,Antonio E. Muruato,Jing Zou,Camila R. Fontes-Garfias,Divya Mirchandani,Dionna Scharton,John P. Bilello,Zhiqiang Ku,Zhiqiang An,Birte Kalveram,Alexander N. Freiberg,Vineet D. Menachery,Xuping Xie,Kenneth S. Plante,Scott C. Weaver,Pei Yong Shi +21 more
TL;DR: Hamsters infected with SARS-CoV-2 expressing spike D614G (G614 virus) produced higher infectious titres in nasal washes and the trachea, but not in the lungs, supporting clinical evidence showing that the mutation enhances viral loads in the upper respiratory tract of COVID-19 patients and may increase transmission.
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Angiotensin?converting enzyme 2 (ACE2), SARS?CoV?2 and the pathophysiology of coronavirus disease 2019 (COVID?19)
Arno R. Bourgonje,Amaal Eman Abdulle,Wim Timens,Jan-Luuk Hillebrands,Gerjan Navis,Sanne J. Gordijn,Marieke C. Bolling,Gerard Dijkstra,Adriaan A. Voors,Albert D. M. E. Osterhaus,Peter H. J. van der Voort,Douwe J. Mulder,Harry van Goor +12 more
TL;DR: The role of ACE2 in CO VID‐19 pathophysiology is described, including factors influencing ACE2 expression and activity in relation to COVID‐19 severity, and the relevant pathological changes resulting from SARS‐CoV‐2 infection are discussed.