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Coronary artery anomalies in 126,595 patients undergoing coronary arteriography.

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TLDR
Coronary artery anomalies were found in 1,686 patients undergoing coronary arteriography at the Cleveland Clinic Foundation from 1960 to 1988 and usually were discovered as incidental findings at the time of catheterization.
Abstract
Coronary artery anomalies were found in 1,686 patients (13% incidence) undergoing coronary arteriography at the Cleveland Clinic Foundation from 1960 to 1988 Of the 1,686 patients, 1,461 (87%) had anomalies of origin and distribution, and 225 (13%) had coronary artery fistulae Most coronary anomalies did not result in signs, symptoms, or complications, and usually were discovered as incidental findings at the time of catheterization Eighty-one percent were “benign” anomalies: (1) separate origin of the left anerior descending and circumflex from the left sinus of Valsalva; (2) ectopic origin of the circumflex from the right sinus of Valsalva; (3) ectopic coronary origin from the posterior sinus of Valsalva; (4) anomalous coronary origin from the ascending aorta; (5) absent circumflex; (6) intercoronary communications; and (7) small coronary artery fistulae Other anomalies may be associated with potentially serious sequelae such as angina pectoris, myocardial infarction, syncope, cardiac arrhythmias, congestive heart failure, or sudden death Potentially serious anomalies include: (1) ectopic coronary origin from the pulmonary artery; (2) ectopic coronary origin from the opposite aortic sinus; (3) single coronary artery; and (4) large coronary fistulae Coronary artery anomalies require accurate recognition, and at times, surgical correction

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Citations
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ACC/AHA 2008 Guidelines for the Management of Adults With Congenital Heart Disease

TL;DR: In this article, the use of diagnostic procedures and therapies introduced and tested for detection, management, or prevention of disease is discussed. But, the focus is on the medical profession.
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Coronary Anomalies Incidence, Pathophysiology, and Clinical Relevance

TL;DR: By determining the incidence of anatomic variants in a large population, acceptable definitions of normal and anomalous anatomy could be established and the clinical importance of anomalous variants ascertained and the rational paradigm generated would generate a rational paradigm.
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Anomalous origin of coronary arteries and risk of sudden death: A study based on an autopsy population of congenital heart disease

TL;DR: All but two patients with sudden death had anomalous coronary artery origin from the aorta itself, and palpitations, syncope, and ventricular arrhythmias were the only prodromic symptoms and signs.
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Coronary artery fistulas : Clinical and therapeutic considerations

TL;DR: Cardiac catheterization and coronary angiography is necessary for the precise delineation of coronary anatomy, for assessment of hemodynamics, and to show the presence of concomitant atherosclerosis and other structural anomalies.
References
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Journal ArticleDOI

Sudden Death as a Complication of Anomalous Left Coronary Origin From the Anterior Sinus of Valsalva: A Not-So-Minor Congenital Anomaly

TL;DR: In this paper, the authors reviewed 51 such cases from the Armed Forces Institute of Pathology congenital heart disease accessions and concluded that where the left coronary artery does not pass acutely posterior and leftward between the pulmonary artery and the aorta there is no risk of sudden death.
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Anomalous origin of the left coronary artery from the pulmonary trunk. Its clinical spectrum, pathology, and pathophysiology, based on a review of 140 cases with seven further cases

TL;DR: Although the greatest surgical therapy experience has been with obliteration of the anomalous left coronary artery at its connection with the pulmonary artery, anastomosis between aorta and ALCA provides an additive supply for both the present and the future.
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Isolated single coronary artery: diagnosis, angiographic classification, and clinical significance.

TL;DR: Typical angina did not occur with single coronary artery in the absence of coexisting coronary artery disease or aortic stenosis, and a new classification is proposed, according to the site of origin and anatomical distribution of the branches.
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Major anomalies of coronary arterial origin seen in adulthood.

TL;DR: Anomalies of origin are particularly common in hearts in which other major congenital cardiovascular malformations are present and will be limited to those anomalies of origin observed in hearts without other major mal Formations of the heart or great vessels.
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Clinical, angiographic, and hemodynamic findings in patients with anomalous origin of the coronary arteries.

TL;DR: It is concluded that anomalous left coronary origin from the right sinus of Valsalva can result in significant myocardial ischemia and infarction.
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