Cortical Activations During Auditory Verbal Hallucinations in Schizophrenia: A Coordinate-Based Meta-Analysis
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...A meta-analysis of fMRI studies of active auditory hallucinations reveals prominent involvement of the insula, bilateral Broca area and auditory cortex.(108) Evidence from the analysis of whole brain structure in hallucinating patients consistently implicates insular deficits....
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...However, insular activation during hallucinations suggests that the salience network is generating an inappropriate proximal salience during an otherwise normal activity.(108) In particular, such an aberrant activation of the insula is noted alongside a prominent absence of cingulate activation, suggesting disruption in normal salience network activity(126) and perhaps disruption to error-monitoring circuitry....
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...Recent meta-analyses of symptomcapture studies have come to only partially overlapping conclusions: while Jardri et al. (2011) found AVHs to be associated with activation in left IFG, anterior insula, superior temporal, and hippocampal areas, Kühn and Gallinat (2012) could only find consistent…...
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Cites background from "Cortical Activations During Auditor..."
...deficits in AH.(22) While cognitive evidence for attention and working memory updating remains inconclusive, the role of attention is clearly relevant in early auditory sensory detection mechanisms....
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...This is thought to arise from hyperactivation in functional networks involving the auditory cortex that generate aberrant auditory signals, possibly due to a deviant trigger of activations in language-related areas responsible for AH.(22,53) Anomalous activations might be determined by environmental factors and/or internal (eg, emotional) conditions....
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