Journal ArticleDOI
Coumarin: a potential nucleus for anti-inflammatory molecules
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TLDR
A critical analysis of various reports on naturally as well as the synthetically derived coumarin derivatives having anti-inflammatory activity has been carried out and a structural–activity relationship around the cou marin nucleus has been proposed to assist the medicinal chemists in rationally designing the anti- inflammatory drugs.Abstract:
Numerous research reports have indicated the coumarin nucleus as a potential candidate for development of anti-inflammatory drugs. Various phytoconstituents such as umbelliferone, scopoletin, columbiatnetin, visniadin, marmin, and many more derived from coumarin nucleus are found to have potent anti-inflammatory as well as antioxidant activities. A large number of coumarin derivatives have also been designed, synthesized, and evaluated to have mild-to-very potent anti-inflammatory activity through different mechanisms. However, despite the continuing efforts in search of these drugs, no major breakthrough has been achieved so far. In the present review, a critical analysis of various reports on naturally as well as the synthetically derived coumarin derivatives having anti-inflammatory activity has been carried out and a structural–activity relationship around the coumarin nucleus has been proposed to assist the medicinal chemists in rationally designing the anti-inflammatory drugs.read more
Citations
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Journal ArticleDOI
Coumarins as anticancer agents: A review on synthetic strategies, mechanism of action and SAR studies
TL;DR: This is the first standalone review that emphasis on the assorted retrosynthetic approaches, important targets for molecularly targeted cancer therapy and structure activity relationship studies that highlight the chemical groups responsible for evoking the anticancer potential of coumarin derivatives reported from 2011 to 2014.
Journal ArticleDOI
Coumarin heterocyclic derivatives: chemical synthesis and biological activity
Fernanda G. Medina,Joaquín G. Marrero,Mariana Macías-Alonso,Magdalena C. Gonzalez,Iván Córdova-Guerrero,Ariana G. Teissier Garcia,Soraya Osegueda-Robles +6 more
TL;DR: This review highlights the broad range of science that has arisen from the synthesis of coumarin-linked and fused heterocycle derivatives and their synthesis and biological activity.
Journal ArticleDOI
Coumarin hybrids as novel therapeutic agents.
TL;DR: The present review compiles research reports on development of different coumarin hybrids, classify these on the basis of their therapeutic uses and propose structure-activity relationships to help medicinal chemist in designing and synthesizing novel and potent hybrid compounds for the treatment of different disorders.
Journal ArticleDOI
Visible-Light-Driven Alkyne Hydro-/Carbocarboxylation Using CO2 via Iridium/Cobalt Dual Catalysis for Divergent Heterocycle Synthesis
TL;DR: An unprecedented cobalt carboxylation/acyl migration cascade enables alkyne difunctionalization to introduce γ-hydroxybutenolides with high efficiency and it is expected that this cascade strategy will inspire new perspectives forAlkyne and alkene difunctionsalization.
Book ChapterDOI
Coumarins — An Important Class of Phytochemicals
Maria João Matos,Lourdes Santana,Eugenio Uriarte,Orlando A. Abreu,Enrique Molina,Estela Guardado Yordi +5 more
TL;DR: There may be as many as 4,000 different phytochemicals having potential activity against several diseases such as cancer and metabolic or degenerative diseases, but not all are established as essential nutrients.
References
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