Coumarins of the root bark of Feronia elephantum
About: This article is published in Phytochemistry.The article was published on 1973-01-01. It has received 25 citations till now. The article focuses on the topics: Bark & Marmesin.
Citations
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TL;DR: Bioassay guided fractionation of the acetone extract of Feronia limonia dried leaves afforded a potent mosquito larvicide, identified as n-hexadecanoic acid and found to be effective against fourth instar larvae of Culex quinquefasciatus, Anopheles stephensi and Aedes aegypti.
262 citations
TL;DR: The biogenesis, structural diversity and distribution of simple, furano- and pyranocoumarins in the Rutaceae is reviewed and the potential value of these compounds as taxonomic markers and their possible functions are discussed.
134 citations
TL;DR: The stem bark of Feronia limonia yielded (-)-(2S)-5,3'-dihydroxy-4'-methoxy-6",6"-dimethylchromeno-(7,8,2",3")-flavanone along with several known compounds including an alkaloid, five coumarins, a flavanone, a lignan, three sterols and a triterpene.
77 citations
TL;DR: The present results suggest that terpenylated coumarins from A. altissima have a direct stimulatory effect on SIRT1 deacetylation activity and may serve as lead molecules for the treatment of some age-related disorders.
Abstract: Four new terpenylated coumarins (1–4) were isolated from the stem bark of Ailanthus altissima by bioactivity-guided fractionation using an in vitro SIRT1 deacetylation assay Their structures were identified as (2′R,3′R)-7-(2′,3′-dihydroxy-3′,7′-dimethylocta-6′-enyloxy)-6,8-dimethoxycoumarin (1), 6,8-dimethoxy-7-(3′,7′-dimethylocta-2′,6′-dienyloxy)coumarin (2), (2′R,3′R,6′R)-7-(2′,3′-dihydroxy-6′,7′-epoxy-3′,7′-dimethyloctaoxy)-6,8-dimethoxycoumarin (3), and (2′R,3′R,4′S,5′S)-6,8-dimethoxy-7-(3′,7′-dimethyl-4′,5′-epoxy-2′-hydroxyocta-6′-enyloxy)coumarin (4) Compounds 1–4 strongly enhanced SIRT1 activity in an in vitro SIRT1-NAD/NADH assay and an in vivo SIRT1-p53 luciferase assay These compounds also increased the NAD-to-NADH ratio in HEK293 cells The present results suggest that terpenylated coumarins from A altissima have a direct stimulatory effect on SIRT1 deacetylation activity and may serve as lead molecules for the treatment of some age-related disorders
36 citations
TL;DR: In this paper, a monoterpenoidfuranocoumarin lactone (fernolin) along with aurapten, marmesin, bergapten and xanthotoxin has been isolated from the roots of Feronia limonia.
31 citations
References
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TL;DR: The mass spectra of some naturally occurring and synthetic α- and γ-pyrones, benzofurans, and 2,2-dimethylchromenes have been determined as mentioned in this paper.
Abstract: The mass spectra of some naturally occurring and synthetic α- and γ-pyrones, benzofurans, and 2,2-dimethylchromenes have been determined. Under electron impact compounds derived from coumarin lose oxygen atoms as CO, usually forming a stable benzofuran ion. 2,2-Dimethylchromenes lose a methyl radical to give a stable benzopyrylium ion, while the most prominent fission of flavanoid compounds occurs by breaking both bonds β to the A ring.
151 citations
TL;DR: Two new coumarins from Choisya arizonica and C. mollis and 2′,3′-dihydroxydihydrosuberosin from Coleonema album have been isolated and their structures determined.
74 citations
32 citations
19 citations
TL;DR: Durch Abbau und Synthese wurde gezeigt, das in dem aus der Wurzelrinde von Feronia elephantum isolierten Feronialacton der Geranylather des 7-Hydr-oxy-cumarins vorliegt as mentioned in this paper.
Abstract: Durch Abbau und Synthese wurde gezeigt, das in dem aus der Wurzelrinde von Feronia elephantum isolierten Feronialacton der Geranylather des 7-Hydr-oxy-cumarins vorliegt.
3 citations