COVID-19 in patients with HIV: clinical case series.
José Luis Santiago Blanco,Juan Ambrosioni,Felipe García,Esteban Martínez,Alex Soriano,Josep Mallolas,José M. Miró +6 more
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TLDR
The first single-centre experience of COVID-19 in patients infected with HIV-1 is described, to the authors' knowledge, including clinical characteristics, antiviral and antiretroviral treatment, and outcomes.About:
This article is published in The Lancet HIV.The article was published on 2020-04-15 and is currently open access. It has received 358 citations till now.read more
Citations
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Risk factors for COVID-19 death in a population cohort study from the Western Cape Province, South Africa.
TL;DR: While the findings may over-estimate HIV- and tuberculosis-associated COVID-19 mortality risks due to residual confounding, both HIV and current tuberculosis were independently associated with increased COVID,19 mortality.
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COVID-19 in Immunocompromised Hosts: What We Know So Far.
Monica Fung,Jennifer M. Babik +1 more
TL;DR: This work reviews the existing literature on COVID-19 among immunocompromised populations ranging from cancer patients and solid organ transplant recipients to patients with HIV and those receiving immunomodulatory therapy for autoimmune disease and concludes that further prospective, controlled studies are needed to determine the attributable risk of Immunocompromising conditions and therapies.
Journal ArticleDOI
Clinical, molecular, and epidemiological characterization of the SARS-CoV-2 virus and the Coronavirus Disease 2019 (COVID-19), a comprehensive literature review.
Esteban Ortiz-Prado,Katherine Simbaña-Rivera,Lenin Gómez Barreno,Mario Rubio-Neira,Linda P. Guaman,Nikolaos C Kyriakidis,Claire Muslin,Ana Maria M Gomez Jaramillo,Carlos Barba-Ostria,Doménica Cevallos-Robalino,Hugo Sanches-SanMiguel,Luis Unigarro,Rasa Zalakeviciute,Naomi Gadian,Andrés López-Cortés +14 more
TL;DR: A comprehensive literature review of the SARS CoV-2 Virus and the Coronavirus Diseases 2019 (COVID-19) is conducted to offer a clear insight of the extensive literature available.
Journal ArticleDOI
Description of COVID-19 in HIV-infected individuals: a single-centre, prospective cohort.
Pilar Vizcarra,María J Pérez-Elías,Carmen Quereda,Ana Moreno,Maria Jesús Vivancos,Fernando Dronda,Jose L Casado,Santiago Moreno,Maria Jesús Pérez-Elías,Jesús Fortún,Enrique Navas,Santos del Campo,Rogelio López-Vélez,Javier Cobo Reinoso,José L. Casado,Franceca Norman,Pilar Martín-Dávila,José Hermida,José Antonio Pérez Molina,Begoña Monge,Vicente Pintado,Sergio Serrano-Villar,Matilde Sánchez-Conde,Sandra Chamorro,Rosa Escudero,Francesca Gioia,Belén Comeche,Clara Crespillo,Sabina Herrera,Raquel Ron,Javier Martínez-Sanz,Mario Pons-Guillén,María J Vivancos +32 more
TL;DR: HIV-infected individuals with COVID-19 should not be considered to be protected from SARS-CoV-2 infection or to have lower risk of severe disease, and they should receive the same treatment approach applied to the general population.
Journal ArticleDOI
HIV infection and COVID-19 death: a population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform.
Krishnan Bhaskaran,Christopher T Rentsch,Brian MacKenna,Anna Schultze,Amir Mehrkar,Chris Bates,Rosalind M Eggo,Caroline E Morton,Sebastian Bacon,Peter Inglesby,Ian J. Douglas,Alex J Walker,Helen Mcdonald,Jonathan Cockburn,Elizabeth A. Williamson,David M. Evans,Harriet Forbes,Helen J Curtis,William J Hulme,John Parry,Frank Hester,Sam Harper,Stephen J. W. Evans,Stephen J. W. Evans,Liam Smeeth,Ben Goldacre +25 more
TL;DR: People with HIV in the UK seem to be at increased risk of COVID-19 mortality, and targeted policies should be considered to address this raised risk as the pandemic response evolves.
References
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Clinical Characteristics of Coronavirus Disease 2019 in China.
Wei-jie Guan,Zhengyi Ni,Yu Hu,Wenhua Liang,Chun-Quan Ou,Jianxing He,Lei Liu,Hong Shan,Chunliang Lei,David S.C. Hui,Bin Du,Lanjuan Li,Guang Zeng,Kowk-Yung Yuen,Ruchong Chen,Chun-Li Tang,Tao Wang,Ping-Yan Chen,Jie Xiang,Shiyue Li,Jinlin Wang,Zi-jing Liang,Yi-xiang Peng,Li Wei,Yong Liu,Ya-hua Hu,Peng Peng,Jian-ming Wang,Ji-yang Liu,Zhong Chen,Gang Li,Zhi-jian Zheng,Shao-qin Qiu,Jie Luo,Chang-jiang Ye,Shao-yong Zhu,Nanshan Zhong +36 more
TL;DR: During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness, and patients often presented without fever, and many did not have abnormal radiologic findings.
Journal ArticleDOI
A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19.
Bin Cao,Yeming Wang,Danning Wen,Wen Liu,Jingli Wang,Guohui Fan,Lianguo Ruan,Bin Song,Yanping Cai,Ming Wei,Xingwang Li,Jia'an Xia,Nanshan Chen,Jie Xiang,Ting Yu,Tao Bai,Xuelei Xie,Li Zhang,Caihong Li,Ye Yuan,Hua Chen,Huadong Li,Hanping Huang,Shengjing Tu,Fengyun Gong,Ying Liu,Yuan Wei,Chongya Dong,Fei Zhou,Xiaoying Gu,Jiuyang Xu,Zhibo Liu,Yi Zhang,Li Hui,Lianhan Shang,Ke Wang,Kunxia Li,Xia Zhou,Xuan Dong,Zhaohui Qu,Sixia Lu,Xujuan Hu,Shunan Ruan,Shanshan Luo,Jing Wu,Lu Peng,Fang Cheng,Lihong Pan,Jun Zou,Chunmin Jia,Juan Wang,Xia Liu,Shuzhen Wang,Xudong Wu,Qin Ge,Jing He,Haiyan Zhan,Fang Qiu,Li Guo,Chaolin Huang,Thomas Jaki,Frederick G. Hayden,Peter Horby,Dingyu Zhang,Chen Wang +64 more
TL;DR: In hospitalized adult patients with severe Covid-19, no benefit was observed with lopinavir–ritonavir treatment beyond standard care, and future trials in patients withsevere illness may help to confirm or exclude the possibility of a treatment benefit.
Journal ArticleDOI
Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV.
Timothy P. Sheahan,Amy C. Sims,Sarah R. Leist,Alexandra Schäfer,John J. Won,Ariane J. Brown,Stephanie A. Montgomery,Alison Hogg,Darius Babusis,Michael O'neil Hanrahan Clarke,Jamie E. Spahn,Bauer Laura Elizabeth,Scott P. Sellers,Danielle P. Porter,Joy Y. Feng,Tomas Cihlar,Robert Jordan,Mark R. Denison,Ralph S. Baric +18 more
TL;DR: Remdesivir (RDV) has superior anti-MERS activity in vitro and in vivo compared to combination therapy with lopinavir, ritonavir and interferon beta and reduces severe lung pathology.
Journal ArticleDOI
Co-infection of SARS-CoV-2 and HIV in a patient in Wuhan city, China.
TL;DR: This report reports on an identified unique severe case involving co‐infection of SARS‐CoV‐2 and HIV, which was referred, quarantined and treated in Wuhan Tongji Sino‐French New Town Hospital, a designated medical institution for the novel coronavirus infection.
Journal ArticleDOI
Reply to Comments on 'Co-infection of SARS-CoV-2 and HIV in a patient in Wuhan city, China'.
TL;DR: This case of co‐infection of SARS‐CoV‐2 and HIV has raised the interests of the HIV research community and the World Health Organiztion declared the COVID‐19 crisis a global pandemic.
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Description of COVID-19 in HIV-infected individuals: a single-centre, prospective cohort.
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