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Open AccessJournal ArticleDOI

Covid-19: Moderna vaccine is nearly 95% effective, trial involving high risk and elderly people shows

Elisabeth Mahase
- 17 Nov 2020 - 
- Vol. 371
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TLDR
The UK government has secured five million doses of the covid-19 vaccine candidate mRNA-1273 from US biotech company Moderna after interim analysis of its phase III trial showed it was 94.5% effective.
Abstract
The UK government has secured five million doses of the covid-19 vaccine candidate mRNA-1273 from US biotech company Moderna after interim analysis of its phase III trial showed it was 94.5% effective. If the vaccine meets standards of safety and effectiveness and is approved by the medicines regulator, the vaccine could be delivered to the UK and Europe as early as spring 2021 with the potential to procure more doses next year, a government statement said. The trial’s Data Safety Monitoring Board—which was appointed by the US National Institute of Health—carried out the analysis based on 95 covid-19 cases, of which 90 were observed in the placebo group and five were reported in the vaccine group. The trial enrolled more than 30 000 US participants, including 7000 aged over 65 and 5000 under 65 with high risk chronic diseases. More than one third (37%) of the trial …

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High Rates of COVID-19 Vaccine Hesitancy and Its Association with Conspiracy Beliefs: A Study in Jordan and Kuwait among Other Arab Countries

TL;DR: In this paper, the authors assess the attitudes towards the prospective COVID-19 vaccines among the general public in Jordan, Kuwait and other Arab countries, and assess the association between COVID19 vaccine acceptance and conspiracy beliefs.
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Understanding Drivers of Coronavirus Disease 2019 Vaccine Hesitancy Among Blacks.

TL;DR: The authors conducted focus groups with black barbershop and salon owners living in zip codes of elevated COVID-19 prevalence to assess their attitudes, beliefs, and norms around a COVID19 vaccine.
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Covid-19: Where are we on vaccines and variants?

Elisabeth Mahase
- 02 Mar 2021 - 
TL;DR: Mahase as mentioned in this paper reports on the latest developments in vaccines, variants, and diplomacy nearly a year after the WHO declared the covid-19 pandemic, and Elisabeth Mahase reports on vaccine variants, variants and diplomacy.
Journal ArticleDOI

Viral Pandemics of the Last Four Decades: Pathophysiology, Health Impacts and Perspectives.

TL;DR: Age- and gender-based characterizations suggest that SARS-CoV-2 resembles SARS/MERS/SARS with regard to higher fatality rates in males, and in the older population with comorbidities, to address the immediate and long-term health consequences.
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Flavonoids are promising safe therapy against COVID-19.

TL;DR: In this paper, the potential inhibitory mechanisms of flavonoids against SARS-CoV-2 infection and their significant immunomodulatory activities were mapped and compared to elect major flavonoid with a promising role in the current pandemic.
References
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Journal ArticleDOI

Covid-19: Vaccine candidate may be more than 90% effective, interim results indicate

Elisabeth Mahase
- 09 Nov 2020 - 
TL;DR: A vaccine candidate developed by Pfizer and BioNTech may be more than 90% effective in preventing covid-19 in participants without prior infection, the first interim analysis of the phase III trial shows.
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