COVID-19-related Genes in Sputum Cells in Asthma. Relationship to Demographic Features and Corticosteroids.
Citations
988 citations
345 citations
273 citations
242 citations
Cites result from "COVID-19-related Genes in Sputum Ce..."
...Intriguingly, Peters and colleagues found that asthmatic subjects treated with inhaled corticosteroids (ICS) had low ACE2 expression compared with untreated subjects, a finding suggesting that ICS treatment could be a predictor of decreased susceptibility to SARS-CoV-2 infection [40]....
[...]
229 citations
Cites background from "COVID-19-related Genes in Sputum Ce..."
...associated with the reduction of expression of both ACE2 and TMPRSS2 (a host serine 419 protease critical to spike protein priming for cell entry) in asthmatics from the Severe 420 Asthma Research Program (SARP) cohort.(28) A separate, preliminary, in vitro study with 421...
[...]
References
22,622 citations
17,014 citations
"COVID-19-related Genes in Sputum Ce..." refers methods in this paper
...Variance stabilization transformation implemented in DESeq2 was then performed on the raw gene count matrix to create a variancestabilized gene expression matrix suitable for downstream analyses (15)....
[...]
15,744 citations
"COVID-19-related Genes in Sputum Ce..." refers methods in this paper
...Gene quantification was performed with htseq-count using GRCh38 ensemble v84 gene transcript model (14)....
[...]
15,362 citations
"COVID-19-related Genes in Sputum Ce..." refers background in this paper
...ACE2 and TMPRSS2 expression mediate SARS-CoV-2 infection of host lung cells (3), and it is reasonable to infer that increases in their expression in lung cells will increase susceptibility to SARS-CoV-2 infection or lead to more severe COVID-19 disease....
[...]
...TMPRSS2 is a transmembrane protease that modifies spike proteins in multiple viruses—including SARS-CoV, SARS-CoV2, Middle East Respiratory Syndrome–CoV, and influenza A and B—to promote viral infection and spread (3)....
[...]
...The S (spike) protein of SARS-CoV-2 binds the ACE1 (angiotensin converting enzyme 2) receptor to mediate virus attachment to host cell membranes, and virus cell entry also depends on S protein priming by host cell proteases, including TMPRSS2 (transmembrane protease, serine 2) (2, 3)....
[...]
...Although recently identified as the SARS-CoV-2 receptor, ACE2 has previously been studied for its role in angiotensin biology (2, 3, 19)....
[...]
13,192 citations
"COVID-19-related Genes in Sputum Ce..." refers methods in this paper
...Trimmed reads were then aligned to the human reference genome GRCh38 using HiSat2 with default parameters (13)....
[...]