COVID-19 risk and outcomes in adult asthmatic patients treated with biologics or systemic corticosteroids: Nationwide real-world evidence.
Reads0
Chats0
TLDR
In this article, the association between biologics or systemic corticosteroids use and PCR positivity for SARS-CoV-2 and coronavirus disease 2019 (COVID-19) outcomes among asthmatic patients was determined.Abstract:
Background Managing severe asthma during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is challenging, particularly due to safety concerns regarding the use of systemic corticosteroids and biologics. Objectives We sought to determine the association between biologics or systemic corticosteroids use and PCR positivity for SARS-CoV-2 and coronavirus disease 2019 (COVID-19) outcomes among asthmatic patients. Methods We used the computerized database of Clalit Health Services, the largest health care provider in Israel, to identify all asthmatic adult patients who underwent PCR testing for SARS-CoV-2, between March 1, 2020, and December 7, 2020. A cohort approach was used to assess the association between biologics use and steroids treatment and COVID-19 severity and 90-day mortality. Results Overall, 8,242 of 80,602 tested asthmatic patients had positive PCR testing result for SARS-CoV-2. Both biologics and systemic corticosteroids were not associated with increased risk of SARS-CoV-2 infection. Multivariate analyses revealed that biologics were not associated with a significantly increased risk of moderate to severe COVID-19, nor with the composite end point of moderate to severe COVID-19 or all-cause mortality within 90 days. Chronic systemic corticosteroid use was associated with significantly increased risk of all tested outcome. Recent (within the previous 120 days) systemic corticosteroid use, but not former use, was significantly associated with increased risk of both moderate to severe COVID-19 and the composite of moderate to severe COVID-19 or all-cause mortality. Conclusions Biologics approved for asthma and systemic corticosteroids are not associated with increased risk of SARS-CoV-2 infection. In contrast, systemic corticosteroids are an independent risk factor for worst COVID-19 severity and all-cause mortality. Our findings underscore the risk of recent or current exposure to systemic corticosteroids in asthmatic patients infected with SARS-CoV-2.read more
Citations
More filters
Journal ArticleDOI
Association of Vitamin D receptor gene polymorphisms and clinical/severe outcomes of COVID-19 patients.
Rasoul Abdollahzadeh,Mohammad Hossein Shushizadeh,Mina Barazandehrokh,Sepideh Choopani,Asaad Azarnezhad,Sahereh Paknahad,Maryam Pirhoushiaran,S. Zahra Makani,Razieh Zarifian Yeganeh,Ahmed Al-Kateb,Roozbeh Heidarzadehpilehrood +10 more
TL;DR: In this paper, the association of VDR gene polymorphisms with severity, clinical outcomes, and comorbidities were evaluated through the calculation of the Odds ratio (OR).
Journal ArticleDOI
COVID-19 Infections and Asthma
TL;DR: Zhang et al. as discussed by the authors found that patients with asthma can have up to 50% reduction in angiotensin-converting enzyme-2 receptor expression, which may be explained in part by the decreasing gradient of angio-ensin converting enzyme 2 receptor from the upper to lower respiratory epithelium.
Journal ArticleDOI
COVID-19 Vaccination for Endocrine Patients: A Position Statement from the Korean Endocrine Society.
Cheol Ryong Ku,Kyong Yeun Jung,Chang Ho Ahn,Jun Sung Moon,Ju Hee Lee,Eun Heui Kim,Hyemi Kwon,Hee Kyung Kim,Sunghwan Suh,Sangmo Hong,Jeonghoon Ha,Eun Roh,Jin Hwa Kim,Mi-Kyung Kim +13 more
TL;DR: In this article, the authors present the medical background of COVID-19 vaccination, as well as precautions to prevent the side effects of vaccination in patients with specific endocrine disorders, including adrenal insufficiency, diabetes mellitus, osteoporosis, autoimmune thyroid disease, hypogonadism, and pituitary disorders.
Journal ArticleDOI
SARS-Cov-2 Infection in Severe Asthma Patients Treated With Biologics
Andriana I. Papaioannou,Evangelia Fouka,Nikolaos Tzanakis,Katerina M. Antoniou,Konstantinos Samitas,Eleftherios Zervas,Konstantinos Kostikas,Konstantinos Bartziokas,Konstantinos Porpodis,Despo K. Papakosta,Argyris Tzouvelekis,Irini Gerogianni,Ourania S. Kotsiou,Michael Makris,Nikoletta Rovina,Garyfallia Vlachou,Miltiadis Markatos,Stelios Vittorakis,Konstantinos Katsoulis,Ilias Papanikolaou,Andreas Afthinos,Paraskevi Katsaounou,Paschalis Steiropoulos,Dimitrios Latsios,Katerina Dimakou,Sofia Koukidou,Georgios Hillas,S. Tryfon,Maria Kallieri,Athina Georgopoulou,P. Avarlis,Petros Bakakos,Katerina Markopoulou,Eleni Gaki,Asimina Paspala,Zacharoula Kyriakaki,Konstantinos I. Gourgoulianis,Spyridon Papiris,Stelios Loukides +38 more
TL;DR: In this article , a cohort of severe asthmatics treated with biologics for the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and disease severity during the COVID-19 pandemic was prospectively observed.
Journal ArticleDOI
The Use of Proton Pump Inhibitors and COVID-19: A Systematic Review and Meta-Analysis
Kaneez Fatima,Talal Almas,Shan Lakhani,Arshia Jahangir,Abdullah Ahmed,Ayra Siddiqui,Aiman Rahim,Saleha Ahmed Qureshi,Zukhruf Arshad,Shilpa Golani,Adeena Musheer +10 more
TL;DR: A systemic literature search from PUBMED, Science Direct, and Cinahl from December 2019 to January 2022 and a systemic review and meta-analysis of 14 studies aimed at addressing the relationship between the use of PPI and the severity of COVID-19 infection found that proton pump inhibitors use was marginally associated with a nominal but statistically significant increase in the risk of infection.
References
More filters
Journal ArticleDOI
Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention
Zunyou Wu,Jennifer M. McGoogan +1 more
TL;DR: Hospitalised COVID-19 patients are frequently elderly subjects with co-morbidities receiving polypharmacy, all of which are known risk factors for d
Journal ArticleDOI
Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area.
Safiya Richardson,Safiya Richardson,Jamie S. Hirsch,Jamie S. Hirsch,Mangala Narasimhan,James M. Crawford,Thomas McGinn,Thomas McGinn,Karina W. Davidson,Karina W. Davidson,Douglas P. Barnaby,Douglas P. Barnaby,Lance B Becker,John Chelico,John Chelico,Stuart L. Cohen,Stuart L. Cohen,Jennifer Cookingham,Kevin Coppa,Michael A Diefenbach,Andrew J. Dominello,Joan Duer-Hefele,Louise Falzon,Jordan Gitlin,Negin Hajizadeh,Negin Hajizadeh,Tiffany G. Harvin,David Hirschwerk,Eun Ji Kim,Eun Ji Kim,Zachary Kozel,Lyndonna Marrast,Lyndonna Marrast,Jazmin N. Mogavero,Gabrielle A. Osorio,Michael Qiu,Theodoros P. Zanos +36 more
TL;DR: This case series provides characteristics and early outcomes of sequentially hospitalized patients with confirmed COVID-19 in the New York City area and assesses outcomes during hospitalization, such as invasive mechanical ventilation, kidney replacement therapy, and death.
Journal ArticleDOI
Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy.
Giacomo Grasselli,Giacomo Grasselli,Alberto Zangrillo,Alberto Zanella,Alberto Zanella,Massimo Antonelli,Massimo Antonelli,Luca Cabrini,Antonio Castelli,Danilo Cereda,Antonio Coluccello,Giuseppe Foti,Roberto Fumagalli,Giorgio Antonio Iotti,Nicola Latronico,Luca Lorini,Stefano Merler,Giuseppe Natalini,Alessandra Piatti,Marco Ranieri,Anna Mara Scandroglio,Enrico Storti,Maurizio Cecconi,Antonio Pesenti,Antonio Pesenti +24 more
TL;DR: Patients with coronavirus disease 2019 (COVID-19) requiring treatment in an intensive care unit (ICU) in the Lombardy region of Italy were characterized, including data on clinical management, respiratory failure, and patient mortality.
Journal ArticleDOI
Factors associated with COVID-19-related death using OpenSAFELY.
Elizabeth A. Williamson,Alex J Walker,Krishnan Bhaskaran,Seb Bacon,Chris Bates,Caroline E Morton,Helen J Curtis,Amir Mehrkar,David M. Evans,Peter Inglesby,Jonathan Cockburn,Helen Mcdonald,Brian MacKenna,Laurie A. Tomlinson,Ian J. Douglas,Christopher T Rentsch,Rohini Mathur,Angel Y S Wong,Richard Grieve,David G. Harrison,Harriet Forbes,Anna Schultze,Richard Croker,John Parry,Frank Hester,Sam Harper,Rafael Perera,Stephen J. W. Evans,Liam Smeeth,Ben Goldacre +29 more
TL;DR: A range of clinical factors associated with COVID-19-related death is quantified in one of the largest cohort studies on this topic so far and includes people of white ethnicity, Black and South Asian people were at higher risk, even after adjustment for other factors.
Related Papers (5)
A prospective multicenter study assessing humoral immunogenicity and safety of the mRNA SARS-CoV-2 vaccines in Greek patients with systemic autoimmune and autoinflammatory rheumatic diseases
Athanasios G. Tzioufas,Athanasios-Dimitrios Bakasis,Andreas V. Goules,Kleopatra Bitzogli,Ilir I. Cinoku,L. Chatzis,Ourania D Argyropoulou,Aliki I. Venetsanopoulou,Maria Mavrommati,Ioanna E Stergiou,V. Pezoulas,Paraskevi V. Voulgari,Chaido Katsimpari,Spyridon Katechis,Souzana Gazi,Gkikas Katsifis,Charalampos I. Sfontouris,Athanasios Georgountzos,Stamatis-Nick C. Liossis,Charalampos Papagoras,Dimitrios I. Fotiadis,Fotini N. Skopouli,Panayiotis G. Vlachoyiannopoulos,Haralampos M. Moutsopoulos +23 more