Covid-19: What have we learnt about the new variant in the UK?
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The new SARS-CoV-2 variant has evoked scenes reminiscent of the early days of covid-19 when much of the world banned travel to and from Wuhan, China as mentioned in this paper.Abstract:
The new SARS-CoV-2 variant has evoked scenes reminiscent of the early days of covid-19 when much of the world banned travel to and from Wuhan, China. With large parts of south-east England locked down, Elisabeth Mahase looks at what we know so farread more
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Journal ArticleDOI
Estimating epidemiologic dynamics from cross-sectional viral load distributions.
James A. Hay,Lee Kennedy-Shaffer,Lee Kennedy-Shaffer,Sanjat Kanjilal,Sanjat Kanjilal,Niall J. Lennon,Stacey Gabriel,Marc Lipsitch,Michael J. Mina +8 more
TL;DR: In this paper, the authors show that the population distribution of viral loads observed under random or symptom-based surveillance, in the form of cycle threshold (Ct) values obtained from reverse-transcription quantitative polymerase chain reaction testing, changes during an epidemic.
Journal ArticleDOI
Covid-19: What new variants are emerging and how are they being investigated?
TL;DR: The new, more transmissible variant of SARS-CoV-2 found in England is just one of many variations of the virus being detected around the world.
Journal ArticleDOI
Covid-19: Where are we on vaccines and variants?
TL;DR: Mahase as mentioned in this paper reports on the latest developments in vaccines, variants, and diplomacy nearly a year after the WHO declared the covid-19 pandemic, and Elisabeth Mahase reports on vaccine variants, variants and diplomacy.
Journal ArticleDOI
Fab and Fc contribute to maximal protection against SARS-CoV-2 following NVX-CoV2373 subunit vaccine with Matrix-M vaccination.
Matthew J. Gorman,Nita Patel,Mimi Guebre-Xabier,Alex Lee Zhu,Alex Lee Zhu,Caroline Atyeo,Krista M. Pullen,Carolin Loos,Carolin Loos,Yenny Goez-Gazi,Ricardo Carrion,Jing-Hui Tian,Dansu Yuan,Kathryn Bowman,Bin Zhou,Sonia Maciejewski,Marisa McGrath,James Logue,Matthew B. Frieman,David C. Montefiori,Colin Mann,Sharon L. Schendel,Fatima Amanat,Florian Krammer,Erica Ollmann Saphire,Douglas A. Lauffenburger,Ann M. Greene,Alyse D. Portnoff,Michael J. Massare,Larry Ellingsworth,Gregory M. Glenn,Gale Smith,Galit Alter +32 more
TL;DR: In this paper, the authors profiled the humoral immune response in a cohort of non-human primates immunized with a recombinant SARS-CoV-2 spike glycoprotein (NVX CoV2373) at two doses, administered as a single or two-dose regimen.
Posted ContentDOI
Estimating epidemiologic dynamics from cross-sectional viral load distributions.
James A. Hay,Lee Kennedy-Shaffer,Lee Kennedy-Shaffer,Sanjat Kanjilal,Sanjat Kanjilal,Niall J. Lennon,Stacey Gabriel,Marc Lipsitch,Michael J. Mina +8 more
TL;DR: It is shown that the distribution of viral loads, in the form of Cycle thresholds (Ct), from positive surveillance samples at a single point in time can provide accurate estimation of an epidemic's trajectory, subverting the need for repeated case count measurements which are frequently obscured by changes in testing capacity.
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