COVID19-inhibitory activity of withanolides involves targeting of the host cell surface receptor ACE2: insights from computational and biochemical assays.
Rajkumar Singh Kalra,Vipul Kumar,Jaspreet Kaur Dhanjal,Sukant Garg,Xiaoshuai Li,Sunil C. Kaul,Durai Sundar,Renu Wadhwa +7 more
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SARS-CoV-2 outbreak in China in December 2019 and its spread as worldwide pandemic has been a major global health crisis Extremely high infection and mortality rate has severely affected all sectoAbstract:
SARS-CoV-2 outbreak in China in December 2019 and its spread as worldwide pandemic has been a major global health crisis Extremely high infection and mortality rate has severely affected all sectoread more
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Parameter estimation of the incubation period of COVID-19 based on the doubly interval-censored data model.
Ming-Ze Yin,Qing-Wen Zhu,Xing Lü +2 more
TL;DR: Based on the doubly interval-censored data model, Wang et al. as discussed by the authors estimate the parameters of the incubation period of COVID-19 by adopting the maximum likelihood estimation, expectation maximization algorithm and a newly proposed algorithm (expectation mostly conditional maximization, referred as ECIMM).
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Emerging COVID-19 Neurological Manifestations: Present Outlook and Potential Neurological Challenges in COVID-19 Pandemic.
Saikat Dewanjee,Jayalakshmi Vallamkondu,Rajkumar Singh Kalra,Rajkumar Singh Kalra,Nagaprasad Puvvada,Ramesh Kandimalla,P. Hemachandra Reddy +6 more
TL;DR: In this article, the authors provided a comprehensive review of COVID-19-related neurological complications and emphasized the need for their early clinical management in the ongoing CoVID-2019 pandemic.
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Counting on COVID-19 Vaccine: Insights into the Current Strategies, Progress and Future Challenges.
Ramesh Kandimalla,Pratik Chakraborty,Jayalakshmi Vallamkondu,Anupama Chaudhary,Sonalinandini Samanta,P. Hemachandra Reddy,Vincenzo De Feo,Saikat Dewanjee +7 more
TL;DR: In this article, the authors provided insights into the prospects of vaccination against COVID-19 and assessed diverse vaccination strategies including DNA, mRNA, protein subunits, vector-based, live attenuated, and inactivated whole/viral particle-based vaccines.
Journal ArticleDOI
COVID-19, Neuropathology, and Aging: SARS-CoV-2 Neurological Infection, Mechanism, and Associated Complications
Rajkumar Singh Kalra,Jaspreet Kaur Dhanjal,Avtar S. Meena,Vishal C. Kalel,Surya Dahiya,Birbal Singh,Saikat Dewanjee,Ramesh Kandimalla +7 more
TL;DR: In this paper, the authors reviewed SARS-CoV-2 infection and its role in neurological manifestations with an emphasis on the elderly population, and underlined the need for their clinical management in advance.
Journal ArticleDOI
Plant derived active compounds as potential anti SARS-CoV-2 agents: an in-silico study.
Dharmendra Kashyap,Shweta Jakhmola,Deeksha Tiwari,Rajesh Kumar,N.S. Hari Narayana Moorthy,Manivannan Elangovan,Natércia F. Brás,Hem Chandra Jha +7 more
TL;DR: Sarma et al. as discussed by the authors investigated antiviral compounds that may potentially target SARS-CoV-2 antigenic spike (S) and host proteins; angiotensin-converting enzyme2 (ACE2), and transmembrane serine protease2 (TMPRSS2).
References
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A pneumonia outbreak associated with a new coronavirus of probable bat origin
Peng Zhou,Xing-Lou Yang,Xian Guang Wang,Ben Hu,Lei Zhang,Wei Zhang,Hao Rui Si,Yan Zhu,Bei Li,Chao Lin Huang,Hui-Dong Chen,Jing Chen,Yun Luo,Hua Guo,Ren Di Jiang,Meiqin Liu,Ying Chen,Xu Rui Shen,Xi Wang,Xiao Shuang Zheng,Kai Zhao,Quanjiao Chen,Fei Deng,Lin Lin Liu,Bing Yan,Fa Xian Zhan,Yan-Yi Wang,Gengfu Xiao,Zhengli Shi +28 more
TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
Journal ArticleDOI
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Roujian Lu,Xiang Zhao,Juan Li,Peihua Niu,Bo Yang,Honglong Wu,Wenling Wang,Hao Song,Baoying Huang,Na Zhu,Yuhai Bi,Xuejun Ma,Faxian Zhan,Liang Wang,Tao Hu,Hong Zhou,Zhenhong Hu,Weimin Zhou,Li Zhao,Jing Chen,Yao Meng,Ji Wang,Yang Lin,Jianying Yuan,Zhihao Xie,Jinmin Ma,William J. Liu,Dayan Wang,Wenbo Xu,Edward C. Holmes,George F. Gao,George F. Gao,Guizhen Wu,Weijun Chen,Weifeng Shi,Wenjie Tan,Wenjie Tan +36 more
TL;DR: The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans.
Journal ArticleDOI
Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein.
Alexandra C. Walls,Young-Jun Park,M. Alejandra Tortorici,M. Alejandra Tortorici,Abigail Wall,Andrew T. McGuire,Andrew T. McGuire,David Veesler +7 more
TL;DR: It is demonstrating that cross-neutralizing antibodies targeting conserved S epitopes can be elicited upon vaccination, and it is shown that SARS-CoV-2 S uses ACE2 to enter cells and that the receptor-binding domains of Sars- coV- 2 S and SARS S bind with similar affinities to human ACE2, correlating with the efficient spread of SATS among humans.
Journal ArticleDOI
Extra Precision Glide: Docking and Scoring Incorporating a Model of Hydrophobic Enclosure for Protein-Ligand Complexes
Richard A. Friesner,Robert B. Murphy,Matthew P. Repasky,Leah L. Frye,Jeremy R. Greenwood,Thomas A. Halgren,Paul C. Sanschagrin,Daniel T. Mainz +7 more
TL;DR: Enrichment results demonstrate the importance of the novel XP molecular recognition and water scoring in separating active and inactive ligands and avoiding false positives.